Management of Neurofibromatosis Type 1 with Plexiform Neurofibromas (NF1 with PNs)

An overview of neurofibromatosis type 1 and how to diagnose the rare disorder. 

Kaleb H. Yohay, MD, provides insight on plexiform neurofibromas as they relate to neurofibromatosis type 1 and discusses tumor inoperability.

Herbert B. Newton, MD, FAAN, outlines the risk of developing malignant peripheral nerve sheath tumors and the role of multidisciplinary team management for PNs in NF1.

The impact of NF1 with plexiform neurofibromas on a patient’s overall quality of life as well as the impact on caregivers.

A review of the available therapeutic options for the treatment of NF1 with plexiform neurofibromas.

Managing symptoms of pain, decreased mobility, braces, and the psychosocial factors associated with NF1 with plexiform neurofibromas.

The role of MEK inhibitors in treating NF1-related plexiform neurofibromas.

A review of the phase 2 SPRINT study using selumetinib for the treatment of neurofibromatosis type 1 with plexiform neurofibromas.
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