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Dementia and Alzheimer Disease

The NeurologyLive dementia and Alzheimer disease clinical focus page provides information, podcasts, videos, and news about the latest FDA actions, clinical guideline updates, study and clinical trial findings, and interviews with physicians related to the care of patients with dementia and similar diseases, including Lewy body dementia, frontotemporal dementia, Alzheimer disease, and more.

Pepinemab’s Upregulation of SEMA4D Expression Warrants Further Development in Huntington, Alzheimer Disease

August 09, 2022

Article

In a phase 2 trial, pepinemab significantly improved metabolic activity as detected by FDG-PET in the majority of brain regions examined, as well as correlated with changes in cognition across both Huntington disease and Alzheimer disease.

Using the Cognitive Stress Test to Distinguish Pre-MCI and Amnestic MCI: Leeron Nahmias, BS

August 09, 2022

Video

The medical student at Nova Southeastern University provided insight on a new innovative tool called the Cognitive Stress Test that can help distinguish different cognitive states for older adults. [WATCH TIME: 6 minutes]

Recognizing Lysosomal Autophagy as a Realistic Target for Alzheimer Disease: Ralph Nixon, MD, PhD

August 08, 2022

Video

The professor of psychiatry and cell biology at NYU Langone pleaded his case for why the Alzheimer community should begin to turn to other drug development strategies, including the relatively young phenomenon of autophagy. [WATCH TIME: 3 minutes]

This Week on NeurologyLive® — August 8, 2022

August 08, 2022

Article

Here's some of what is coming soon to NeurologyLive® this week.

Incorporating Voice Analytics Into Cognitive Assessments: Alvaro Pascual-Leone, MD, PhD

August 07, 2022

Video

The chief medical officer and cofounder of Linus Health provided insight on the outlook of acoustic measures and machine learning to further classify cognitive impairment. [WATCH TIME: 4 minutes]

NeurologyLive® Brain Games: August 7, 2022

August 07, 2022

Article

Test your neurology knowledge with NeurologyLive®'s weekly quiz series, featuring questions on a variety of clinical and historical neurology topics. This week's topic is neuromyelitis optica spectrum disorder.

Using Initial Cognitive Symptoms to Predict Trajectories of Neurodegenerative Pathologies

August 06, 2022

Article

Jagan A. Pillai, MD, PhD, neurologist, Cleveland Clinic Lou Ruvo Center for Brain Health, discussed a recent study which found faster clinical progression in those with nonamnestic initial cognitive symptoms.

Severe Preeclampsia Linked With Neuroinflammation, Neurofilament Light Associated With Memory Function, Discrimination Effects on Cognition

August 06, 2022

Video

Neurology News Network for the week ending August 6, 2022. [WATCH TIME: 4 minutes]

NeurologyLive® Friday 5 — August 5, 2022

August 05, 2022

Article

Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending August 5, 2022.

Risk of Incident Dementia Influenced by Apathy, Cognitive Status, and APOE Genotype in Mild Behavioral Impairment

August 05, 2022

Article

Effect modification by cognitive status and APOE genotype revealed greater effects of mild behavioral impairment with apathy in those who had normal cognition or in non-APOE ɛ4 groups.