Dementia and Alzheimer Disease

The NeurologyLive dementia and Alzheimer disease clinical focus page provides information, podcasts, videos, and news about the latest FDA actions, clinical guideline updates, study and clinical trial findings, and interviews with physicians related to the care of patients with dementia and similar diseases, including Lewy body dementia, frontotemporal dementia, Alzheimer disease, and more.

Episode 24: Aducanumab and Alzheimer Disease Clinical Trials

"Mind Moments," a podcast from NeurologyLive, brings you an exclusive look into the discussion surrounding aducanumab and how it reflects the challenges of conducting clinical trials in Alzheimer disease.

Support, Skepticism, and Statistics: The Aducanumab Saga

After a sudden reversal and complex analyses, aducanumab’s future rests in the hands of the FDA while the community stands split on if the available data are enough to justify an approval.

Compounding Challenges: Conducting Clinical Trials in Alzheimer Disease

Treating Alzheimer disease presents a spiderweb of complexity for physicians, and its intricacies have made assessing therapies equally puzzling.

Negative Impacts on Cognition Not Observed With Pimavanserin for Dementia-Related Psychosis

April 16, 2021

Article

The study presented at the 2021 AAN Meeting follows the complete response letter issued by the FDA to Acadia Pharmaceuticals due to deficiencies in their sNDA.

NeurologyLive Friday 5 — April 16, 2021

April 16, 2021

Article

Take 5 minutes to catch up on NeurologyLive's highlights from the week ending April 16, 2021.

Plasma NfL Offers Better Prognostication for Neurodegeneration Than Total Tau

April 16, 2021

Article

Data from a cohort of more than 900 individuals suggest that while total tau can add cross-sectional value in certain contexts, neurofilament light served better for prognostication of cognitive decline and imaging changes.

Utilizing Aspirin to Lower Stroke Rates in Cerebral Amyloid Antipathy: Sheheryar Jamali, MD

April 16, 2021

Video

The neurologist from Mayo Clinic discussed his abstract at AAN 2021 comparing stroke rates in patients with cerebral amyloid antipathy given treatment with aspirin.

Changing Clinical Care for Neuropsychiatric Symptoms of Dementia: Jacob Mintzer, MD, MBA

April 14, 2021

Video

The professor of health science at the Medical University of South Carolina detailed the limits of what can be achieved with behavioral interventions for the symptoms of dementia.

What to Expect from the 2021 American Academy of Neurology Annual Meeting

April 14, 2021

Article

The 2021 AAN Annual Meeting will be held virtually from April 17-22. Follow along with coverage from NeurologyLive, including expert interviews and session recaps.

Minorites May Receive Less Timely MCI Diagnoses Than White Individuals

April 14, 2021

Article

Researchers analyzed data from the 10,472 Medicare beneficiaries diagnosed with mild cognitive impairment or dementia in California.

Novel Study Explores Approved Drugs With Potential for Alzheimer Disease

April 13, 2021

Article

A group of 15 repurposed agents were identified as the best candidates for activity against the network of 20 related and distinct biochemical pathways that are dysregulated in AD-related dementia.

This Week on NeurologyLive — April 12, 2021

April 12, 2021

Article

Here's what is coming soon to NeurologyLive.

The High-Demand for Neuropsychiatric Symptom Treatment in Dementia: Jacob Mintzer, MD, MBA

April 10, 2021

Video

The professor of health science at the Medical University of South Carolina spoke to the dire need for more therapeutic approaches to treat some of the most difficult symptoms of dementia.