Dementia and Alzheimer Disease

Support, Skepticism, and Statistics: The Aducanumab Saga

After a sudden reversal and complex analyses, aducanumab’s future rests in the hands of the FDA while the community stands split on if the available data are enough to justify an approval.

Compounding Challenges: Conducting Clinical Trials in Alzheimer Disease

Treating Alzheimer disease presents a spiderweb of complexity for physicians, and its intricacies have made assessing therapies equally puzzling.

Episode 24: Aducanumab and Alzheimer Disease Clinical Trials

"Mind Moments," a podcast from NeurologyLive, brings you an exclusive look into the discussion surrounding aducanumab and how it reflects the challenges of conducting clinical trials in Alzheimer disease.

Biogen, Apple to Initiate Study to Develop Cognitive Health Digital Biomarkers

January 16, 2021

Article

Maha Radhakrishnan, MD, the Group SVP and chief medical officer at Biogen, discussed the collaborative study between Biogen and Apple that’s expected to kick off later this year.

Donanemab Shows Decline in Alzheimer, Pfizer DMD Study Launched, REM Not Correlated With Seizures

January 16, 2021

Video

Neurology News Network for the week ending January 16, 2021.

NeurologyLive Friday 5 — January 15, 2021

January 15, 2021

Article

Take 5 minutes to catch up on NeurologyLive's highlights from the week ending January 15, 2021.

P-Tau181 Associated With Longitudinal Neurodegeneration in Alzheimer Disease

January 14, 2021

Article

The findings suggest and confirm previous studies that suggested plasma p-tau181 may be used as a measure to monitor Alzheimer disease progression in clinical practice and treatment trials.

NeuroVoices: Fabio Nascimento, MD, on Improving EEG Education in Residency Programs

January 13, 2021

Article

The clinical fellow at Massachusetts General Hospital detailed his research on neurology resident EEG education, and the increased need for more consistency throughout programs.

Low Amyloid-β Deposition, Dopaminergic Activity Characterize MCI With Lewy Body Dementia

January 12, 2021

Article

Researchers found amyloid-β positron emission tomography imaging and dopamine transporter imaging to be useful in characterizing phenotypes of the neurodegenerative conditions.

SB623 Mesenchymal Stem Cell Implantation Efficacious and Well-Tolerated in TBI

January 11, 2021

Article

There was no statistically significant difference between treatment-related adverse events in the SB623 stem cell and control groups.

Donanemab Shows Slowing of Decline in Alzheimer Phase 2 TRAILBLAZER-ALZ Study

January 11, 2021

Article

The follow-up TRAILBLAZER-EXT and broader population TRAILBLAZER-ALZ 2 studies are currently ongoing.

This Week on NeurologyLive — January 11, 2020

January 11, 2021

Article

Here's what is coming soon to NeurologyLive.

Understanding the Burden of Dementia-related Psychosis

January 08, 2021

Article

Health care professionals and a caregiver discuss the overall burden of hallucinations and delusions associated with dementia-related psychosis, explore unmet needs in diagnosis and management of these symptoms, and discuss the need for increased dialogue between clinicians and caregivers.