Top Medical News

Germinal Center Activity Shows Potential As Target of Rituximab in NMOSD

August 17, 2022

By Matt Hoffman

Data assessing samples of deep cervical lymph node aspirates and blood suggest that germinal center activity was associated with clinical relapses in individuals with neuromyelitis optica spectrum disorder.

Potential Therapeutic Role of the Endocannabinoid System for Migraine

August 17, 2022

By Jennifer S. Sun, PhD

Identified implications of the endocannabinoid system in migraine physiology suggest that this pathway might hold therapeutic potential for some headache disorders.

NeuroVoices: Jessica Caldwell, PhD, on Evaluating Brain Regions and Functional Connectivity to Understand Sex Differences in Cognitive Decline

August 17, 2022

By Marco Meglio

The director of the Women’s Alzheimer’s Movement Prevention Center at Cleveland Clinic discussed new research which looked at the differences in functional connectivity for men and women of older age.

Long-term Immunosuppression Treatment Is Suitable for Patients With NMOSD

August 16, 2022

By Matt Hoffman

Data suggest that long-term treatment with immunosuppression therapies, such as rituximab, is generally appropriate for patients with neuromyelitis optica, though transverse myelitis might indicate a higher risk of relapse post discontinuation.

Highly Effective Gene Therapies for SMA: Where Do We Go From Here?

August 16, 2022

By Elizabeth A. Kichula, MD, PhD

Neuromuscular medicine has entered an era of genetic therapy, opening the doors to questions about possible combination approaches and earlier initiation of treatment.

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Questions of Adherence Raised by Unused Multiple Sclerosis Disease-Modifying Therapies: Darin T. Okuda, MD; Karin Cook

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Stigma Adds to Depressive Symptoms in Epilepsy, Parkinson Disease and Diabetes Show Increased Neuroaxonal Damage, ICER Publishes Report on ALS Treatments

What Proactive Semantic Interference and Persistent PSI Can Reveal About Cognitive Status: Rosie Curiel, PsyD

Understanding the Cognitive Risks With Preeclampsia and Raising Awareness: Vesna Garovic, MD, PhD

Realistic Views for Developing APOE-Targeted Gene Therapies for Alzheimer Disease: Yann Le Guen, PhD

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Passage Bio Doses First Patient in Frontotemporal Dementia Gene Therapy Trial

August 16, 2022

Article

The AAV1 gene therapy, PBFT02, is being assessed in a phase 1/2 trial called upliFT-D (NCT04747431), which is planned to take place over the course of 24 months in patients with frontotemporal dementia with granulin mutations.

CNM-Au8 Displays Positive Topline Results in Multiple Sclerosis, Supportive of Phase 3 Trial

August 16, 2022

Article

Clene Nanomedicine’s gold nanocrystal suspension treatment showed significant improvements in Low Contrast Letter Acuity and Multiple Sclerosis Functional Composite scores among individuals with relapsing multiple sclerosis.

Transcutaneous Auricular Vagus Nerve Stimulation Shows Effectiveness as Parkinson Disease Gait Modulator

August 15, 2022

Article

In the first report evaluating transcutaneous auricular VNS in patients with Parkinson disease, significant changes were observed in stride length, swing amplitude, gait speed, and gait time.

Risk Factors and Disease Progression in Multiple Sclerosis

August 15, 2022

Video

Drs Randall Schapiro and Jeffrey Wilken provide insight into the risk factors and disease progression noted in patients with multiple sclerosis.

Defining Cognitive Impairment and Brain Health in Multiple Sclerosis

August 15, 2022

Video

Experts in neurology comment on the lack of definition of cognitive impairment in multiple sclerosis, highlighting an inability to adequately screen for and measure this disease symptom.

Shifting the Paradigm: Earlier Use of On-Demand Therapy for Treating OFF Time in Parkinson Disease

August 15, 2022

Article

Despite the availability of medications to relieve OFF episodes in Parkinson disease, widespread adoption of on-demand therapies has been less-than-ideal, marking the need to shift the treatment paradigm in PD.

This Week on NeurologyLive® — August 15, 2022

August 15, 2022

Article

Here's some of what is coming soon to NeurologyLive® this week.

Bayesian Approach Helps Integrate Adults MS Trial Data to Children, Providing Clarity on Efficacy of Treatments

August 14, 2022

Article

After failing to show statistical significance in a cohort of children, teriflunomide, the disease-modifying medication observed in the analysis, had compelling evidence to suggest it was efficacious in that age group following the Bayesian approach to analysis.

NeurologyLive® Brain Games: August 14, 2022

August 14, 2022

Article

Test your neurology knowledge with NeurologyLive®'s weekly quiz series, featuring questions on a variety of clinical and historical neurology topics. This week's topic is multiple sclerosis.

Raising the Awareness of Severe Preeclampsia and Recognizing Potential Long-Term Impacts

August 13, 2022

Article

Vesna Garovic, MD, PhD, chair of the nephrology division at Mayo Clinic, discussed the appropriate reaction to data suggesting late-life elevated inflammation and neurovascular damage from severe preeclampsia.

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