Top Medical News

FDA Extends Review of Omaveloxolone in Friedreich Ataxia

August 09, 2022

By Matt Hoffman

After Reata Pharmaceuticals submitted an analysis from the MOXIe extension study of the investigational agent as part of the NDA submission, the FDA extended the PDUFA date to February 2023.

Pepinemab’s Upregulation of SEMA4D Expression Warrants Further Development in Huntington, Alzheimer Disease

August 09, 2022

By Marco Meglio

In a phase 2 trial, pepinemab significantly improved metabolic activity as detected by FDG-PET in the majority of brain regions examined, as well as correlated with changes in cognition across both Huntington disease and Alzheimer disease.

Future Relapse Remission in Multiple Sclerosis Impacted by Retinal Layer Thinning

August 09, 2022

By Marco Meglio

The impact of retinal thinning was higher when using GCIPL rather than pRNFL thinning as it explained more of the variance in relapse remission.

Delayed Diagnosis of Functional Seizures Associated With Abnormal Processing of Face Emotions

August 09, 2022

By Marco Meglio

Increased posterior cingulate cortex activation to sad faces in the long-delay diagnostic group were associated with worse symptoms of depression, as expressed by Beck Depression Inventory scores.

Migraine and Mental Health: Taking Time to Ask the Questions

August 08, 2022

By Matt Hoffman

Lawrence Newman, MD, offered his insight into the findings of a survey conducted by the American Headache Foundation that identified correlations between migraine and mental health conditions.

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Using the Cognitive Stress Test to Distinguish Pre-MCI and Amnestic MCI: Leeron Nahmias, BS

August 09, 2022

Video

The medical student at Nova Southeastern University provided insight on a new innovative tool called the Cognitive Stress Test that can help distinguish different cognitive states for older adults. [WATCH TIME: 6 minutes]

Understanding Cognition and Brain Health in Multiple Sclerosis

August 08, 2022

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Ahmed Obeidat, MD, PhD; Randall Schapiro, MD, FAAN; and Jeffrey Wilken, PhD, comment on early investigations surrounding the impact of multiple sclerosis on cognition and brain health and the current lack of focus regarding its impact on patients.

Evolution and Prevalence of Multiple Sclerosis

August 08, 2022

Video

Ahmed Obeidat, MD, PhD; and Randall Schapiro, MD, FAAN, discuss the prevalence of multiple sclerosis and highlight how the disease has evolved since they began practicing. They also review the impact it has on patients and their support communities.

Characteristics of Bilateral Parafalcine Cortical Leptomeningeal Impairment in NMOSD, MOGAD Identified to Avoid Misdiagnosis

August 08, 2022

Article

BPCLI was observed in both NMOSD and MOGAD but was relatively rarer in AQP4 NMOSD, with meningoencephalitis-like episodes among the sources of misdiagnosis.

This Week on NeurologyLive® — August 8, 2022

August 08, 2022

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Here's some of what is coming soon to NeurologyLive® this week.

ICER Releases Report Comparing Cost-Effectiveness of ALS Agents Oral Edaravone and AMX0035

August 07, 2022

Article

After recently receiving approval in Canada, AMX0035 looks to join the US market alongside riluzole and edaravone, the only FDA-approved therapeutics that slow disease progression in ALS.

NeurologyLive® Brain Games: August 7, 2022

August 07, 2022

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Test your neurology knowledge with NeurologyLive®'s weekly quiz series, featuring questions on a variety of clinical and historical neurology topics. This week's topic is neuromyelitis optica spectrum disorder.

Using Initial Cognitive Symptoms to Predict Trajectories of Neurodegenerative Pathologies

August 06, 2022

Article

Jagan A. Pillai, MD, PhD, neurologist, Cleveland Clinic Lou Ruvo Center for Brain Health, discussed a recent study which found faster clinical progression in those with nonamnestic initial cognitive symptoms.

Advice for Managing Dravet Syndrome and LGS

August 05, 2022

Video

Mary Anne Meskis; Tracy Dixon-Salazar, PhD; Kelly Knupp, MD; and Joseph E. Sullivan, MD, provide advice for physicians treating patients with Dravet syndrome or LGS.

Resources for Dravet Syndrome and LGS

August 05, 2022

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Kelly Knupp, MD; Mary Anne Meskis; and Tracy Dixon-Salazar, PhD, share education around patient advocacy and support groups as well as other resources for patients with Dravet syndrome or LGS.

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