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NeurologyLive® Friday 5 — August 12, 2022

August 12, 2022

By NeurologyLive® Staff

Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending August 12, 2022.

Two Patient Deaths Reported With Zolgensma Administration in SMA

August 12, 2022

By Victoria Johnson

The deaths, occurring shortly after treatment infusion, were because of acute liver injury, which is a known risk associated with the Novartis gene therapy.

Trends in Stroke Incidence for Younger Ages Prompt Need to Reexamine Causes, Prevention Methods

August 12, 2022

By Marco Meglio

When combing all 26 studies irrespective of methods, the lowest age-specific divergence in incidence was seen in 3 Southern European studies, and the most pronounced divergence in North American studies.

Episode 70: Raising Awareness of Acute Flaccid Myelitis

August 12, 2022

By Matt Hoffman

Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with Olwen C. Murphy, MBBCh; and Matthew R. Vogt, MD, PhD.

Overlap Observed Between Perceived Stress, Felt Stigma, and Depressive Symptoms in Epilepsy

August 11, 2022

By Marco Meglio

When each variable was entered into the first step of hierarchical linear regression analysis, perceived stress explained more than 40% of the variance in depressive symptoms, followed by felt stigma, at about 20%.

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Click here to read NeurologyLive®'s NeuroVoices series of in-depth, exclusive conversations with a variety of experts in the care and management of patients with neurologic diseases about topics in clinical care and therapeutic development.

Coverage of the Advanced Therapeutics in Movement and Related Disorders Congress

Get the latest data and clinical news updates, as well as interviews with experts, straight from the conference floor.

Gold Standard Centers

Click here to check out the latest deep dive into examples of institutional success in medicine with our Gold Standard Centers feature series.

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Test your neurology knowledge with NeurologyLive®'s weekly quiz series, featuring questions on a variety of clinical and historical neurology topics.

EEGTalk

EEGTalk is a series dedicated to teaching EEG reading skills in neurology in a way that is both digestible and fun, hosted by Fábio A. Nascimento, MD, and Brandon Westover MD, PhD. Click here to watch.

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Understanding the Cognitive Risks With Preeclampsia and Raising Awareness: Vesna Garovic, MD, PhD

Realistic Views for Developing APOE-Targeted Gene Therapies for Alzheimer Disease: Yann Le Guen, PhD

Redefining, Simplifying the Complexities of Alzheimer Disease and Amyloid Cascade: Ralph Nixon, MD, PhD

Using Functional Connectivity and the Default Network to Uncover Sex-Based Differences: Jessica Caldwell, PhD

The Wide-Reaching Impact of Multiple Sclerosis DMT Wastes: Darin T. Okuda, MD; Karin Cook

Recognizing Lysosomal Autophagy as a Realistic Target for Alzheimer Disease: Ralph Nixon, MD, PhD

Incorporating Voice Analytics Into Cognitive Assessments: Alvaro Pascual-Leone, MD, PhD

Getting Up to Speed on the Evolving Landscape of Multiple Sclerosis: Annette Okai, MD

Severe Preeclampsia Linked With Neuroinflammation, Neurofilament Light Associated With Memory Function, Discrimination Effects on Cognition

Most Recent

Despite Large-Scale Efforts, Inverse Association Between Smoking and Parkinson Disease Remain Unelucidated

August 10, 2022

Article

Valine at position 11, the most significantly associated amino acid, was found in 26% of controls and 22% of individuals with Parkinson disease.

Diabetes Linked With Increased Levels of Neurofilament Light, Neuroaxonal Damage in Parkinson Disease

August 10, 2022

Article

Investigators identified increased levels of neurofilament light that corresponded significantly with patients’ diabetic status, even after adjustment for age, BMI, and vascular risk factors.

NeuroVoices: Vesna Garovic, MD, PhD, on Severe Preclampsia’s Effect on Late-Life Cognition, Neuroinflammation for Women

August 10, 2022

Article

The chair of the nephrology division at Mayo Clinic provided context on new findings on the risks of preeclampsia, a hypertensive disorder, and elevated levels of neuroinflammation and neurovascular damage.

FDA Extends Review of Omaveloxolone in Friedreich Ataxia

August 09, 2022

Article

After Reata Pharmaceuticals submitted an analysis from the MOXIe extension study of the investigational agent as part of the NDA submission, the FDA extended the PDUFA date to February 2023.

Pepinemab’s Upregulation of SEMA4D Expression Warrants Further Development in Huntington, Alzheimer Disease

August 09, 2022

Article

In a phase 2 trial, pepinemab significantly improved metabolic activity as detected by FDG-PET in the majority of brain regions examined, as well as correlated with changes in cognition across both Huntington disease and Alzheimer disease.

Future Relapse Remission in Multiple Sclerosis Impacted by Retinal Layer Thinning

August 09, 2022

Article

The impact of retinal thinning was higher when using GCIPL rather than pRNFL thinning as it explained more of the variance in relapse remission.

Using the Cognitive Stress Test to Distinguish Pre-MCI and Amnestic MCI: Leeron Nahmias, BS

August 09, 2022

Video

The medical student at Nova Southeastern University provided insight on a new innovative tool called the Cognitive Stress Test that can help distinguish different cognitive states for older adults. [WATCH TIME: 6 minutes]

Delayed Diagnosis of Functional Seizures Associated With Abnormal Processing of Face Emotions

August 09, 2022

Article

Increased posterior cingulate cortex activation to sad faces in the long-delay diagnostic group were associated with worse symptoms of depression, as expressed by Beck Depression Inventory scores.

Migraine and Mental Health: Taking Time to Ask the Questions

August 08, 2022

Article

Lawrence Newman, MD, offered his insight into the findings of a survey conducted by the American Headache Foundation that identified correlations between migraine and mental health conditions.

Understanding Cognition and Brain Health in Multiple Sclerosis

August 08, 2022

Video

Ahmed Obeidat, MD, PhD; Randall Schapiro, MD, FAAN; and Jeffrey Wilken, PhD, comment on early investigations surrounding the impact of multiple sclerosis on cognition and brain health and the current lack of focus regarding its impact on patients.

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