Polysomnography More Commonly Used in Narcolepsy Detection Prior to Multiple Sleep Latency Test
A web-based survey of Korean neurologists interested in narcolepsy presented their concerns with using the multiple sleep latency test, noting that it may lead to ambiguous results due to accompanying sleep disorders like sleep apnea.
Combination of CRGP Antagonists Ubrogepant and Atogepant Proves Safe in Phase 1b Trial
A single dose of ubrogepant at its highest FDA-approved strength of 60 mg once daily had no statistically significant effect on atogepant pharmacokinetics.
New Diagnostic Criteria Established for MOGAD, FDA Approves Proclaim XR SCS System, Clinical Hold on IKT-148009 Lifted
Neurology News Network for the week ending February 4, 2023. [WATCH TIME: 4 minutes]
Knowledge and Comfort in Treating Migraine During Pregnancy
The clinical psychologist from Ayer Neuroscience Institute at Hartford Healthcare Headache Center shared some highlights from her recently published survey study on migraine treatment during pregnancy.
National Women Physicians Day: 10 Moments That Matter in Medicine
The list of women's contributions to the field of medicine is a long one, encompassing the hard work of hundreds of individuals. To highlight some of these pioneers, NeurologyLive® has compiled a timeline of 10 of the moments that matter in the history of women in medicine.
NeurologyLive® Friday 5 — February 3, 2023
Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending February 3, 2023.
Educating and Diversifying Clinicians to Help Overcome Gaps in Parkinson Disease Management: Eli Pollard
The chief training and education officer at the Parkinson’s Foundation discussed the importance of educating healthcare professionals on different specialists that play a role in Parkinson disease management. [WATCH TIME: 2 minutes]
Neuro News Roundup: Hot Topics and Key Insights From Women in Medicine
In celebration of Women’s Physician Day, held February 3, 2022, take a look back at some of the latest conversations and news that were driven and delivered by women in neurology.
Adopting the 5-Cog Assessment Nationally, Other Cognitive Conditions: Joe Verghese, MBBS, MS
The director of the Montefiore Einstein Center for the Aging Brain provided insight on expanding the use of the 5-Cog tool, and whether it can be used for other conditions like HIV or COVID-19. [WATCH TIME: 3 minutes]
Early Intervention of Deep Brain Stimulation Results in Improvements in Motor, Non-Motor Symptoms of Parkinson Disease
Treatment with deep brain stimulation resulted in improvements in mean motor scores, reductions levodopa equivalent dosage, and a decrease in neuropsychiatric features.
Clinical Provider Survey Reveals Varied Levels of Comfort for Migraine Treatment During Pregnancy
Majority of women’s healthcare providers reported in a survey feeling either somewhat or very comfortable with recommending or continuing acute treatments for pregnant patients with migraine.
REGENXBIO's Clinical Trial for Duchenne Therapy RGX-202 Begins Patient Recruitment
Recruitment has begun for REGENXBIO's AFFINITY BEYOND clinical trial assessing the prevalence of AAV8 antibodies in male patients with Duchenne muscular dystrophy.
Effective Comparative Research and Potential Treatment Approvals in Epilepsy Care: Anup Patel, MD
The pediatric neurologist at Nationwide Children's Hospital talked about current gaps and potential treatment approvals in epilepsy care for 2023. [WATCH TIME: 4 minutes]
Restless Legs Syndrome Severity in MS Decreased Through Exergaming
An exergaming program that spanned 8 weeks showed positive effects for patients with multiple sclerosis both with and without restless legs syndrome.
Educating and Easing Interdisciplinary Care Teams to Treat Parkinson Disease: Eli Pollard
The chief training and education officer at the Parkinson’s Foundation provided perspective on the vast types of medical professionals who can learn from the organization’s new education series. [WATCH TIME: 4 minutes]
FDA Accepts New Drug Application for Duchenne Therapy Vamorolone
With a PDUFA date of October 26, 2023, the FDA will review data from the phase 2b VISION-DMD study, in which vamorolone met its primary end point in change in TTSTAND velocity.
Novartis Discontinues Huntington Disease Program Following Phase 2b Study
Branaplam, an mRNA splicing modifier, joins the many unsuccessful agents for Huntington disease as biopharma continues to be challenged with trial holds and failures.
5 Clinical Trial Readouts in Neurology to Look for in 2023
Take a look at 5 of the most-anticipated clinical trial data readouts expected in 2023 that neurology health care professionals should keep their eyes on.
Using Deep Brain Stimulation to Treat Alzheimer Disease Symptoms
Donald Whiting, MD, chair of Allegheny Health Network’s Neurosciences Institute, provided insight on ADvance II, a multinational trial exploring the use of deep brain stimulation in patients with mild Alzheimer disease.
State of Mental Health Care for Patients With MS: Dawn Edhe, PhD
The psychologist and professor in the department of rehabilitation medicine at the University of Washington shared her perspective on the state of mental health care in multiple sclerosis. [WATCH TIME: 4 minutes]
NeuroVoices: Rachel Alvarez on Identifying Key Treatment Needs for Congenital Muscular Dystrophies
The executive direct of Cure CMD discussed the state of care for patients with congenital muscular dystrophies, the need for new treatments, and the patience with gene therapies.
Whole Brain Volume Loss, Higher Thalamic and Hippocampal Atrophy Rate Identified in MOGAD
A cross-sectional and longitudinal comparative analysis suggests a subclinical neurodegenerative process may occur in MOG antibody disease based on a distinct pattern of brain atrophy.
Moderate Napping Shows Protective Effects Against Cognitive Decline
Data from a cohort of more than 8000 participants suggest that older adults with less optimal sleep duration might benefit from moderate napping for their cognitive functions.
Shift in Day-to-Day Practices in Epilepsy Care: Anup Patel, MD
The pediatric neurologist at Nationwide Children's Hospital talked about the year-over-year changes in day-to-day clinical practice of patients with epilepsy. [WATCH TIME: 4 minutes]
Case Study and Overview of WAKIX® (pitolisant) Tablets in the Treatment of Excessive Daytime Sleepiness and/or Cataplexy in Adults with Narcolepsy
Antiseizure Agent EQU-001 Shows Safety, Tolerability, and Preliminary Efficacy in Phase 2 Study
In addition to showing a tolerable safety profile, EQU-001 resulted in reduced IL-17 and IL-1b plasma levels relative to baseline and limited the ability of peripheral mononuclear cells to secrete additional pro-inflammatory cytokines.
Understanding Parkinson’s Foundation’s New Community Education Series: Eli Pollard
The chief training and education officer at the Parkinson’s Foundation provided perspective on a recently launched online program aimed at educating healthcare professionals. [WATCH TIME: 3 minutes]
Eptinezumab Shows Positive Effects on Patient-Reported Outcomes in Medication-Overuse Headache from Chronic Migraine
After 12 weeks of treatment, almost twice as many patients on eptinezumab reported either “much improved” or “very much improved” than those on placebo, according to Patient Global Impression of Change.
Relapse Patterns and Disease Phenotype Correlate With Treatment Change in NMOSD
Results from the CIRCLES cohort demonstrated a significant association in relapse patterns and disease phenotype for patients with NMOSD who change treatment.
Despite No Change in Neurofilament, Some Subgroups of Progressive MS Improve With Dimethyl Fumarate
Over a 2-year treatment period, no clear effects of dimethyl fumarate were identified on clinical or MRI outcomes in patients with progressive multiple sclerosis.
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