Research at AAN 2017 highlights research of genes that may help predict the likelihood of developing Parkinson disease and progression of the disease.
Studies from AAN 2017 presented research examining lysosomal storage disorder (LSD) genes associated with risk of Parkinson disease, questioning whether specific mutations of GBA gene impact progression of the disease, and tackling the challenge of utilizing whole-exome sequencing to identify genes linked to Parkinson disease risk in a large cohort of unrelated subjects.From materials presented at AAN Annual Meeting, Boston, MA. Best of: Parkinson Disease session. April 23, 2017.
In addition to GBA, which lysosomal storage disorder (LSD) genes are associated with risk of Parkinson disease?
“We propose an oligogenic model of PD, in which multiple genetic hits may act in combination to degrade lysosomal function, enhancing disease susceptibility.”
Can whole-exome sequencing be used to identify genes linked to Parkinson disease risk in a large cohort of unrelated subjects?