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Marco Meglio
Articles
Tolebrutinib Adds to the Growing Momentum of BTK Inhibitors in MS
November 26, 2021
Article
The Bruton tyrosine kinase inhibitor has been evaluated in 2 phase 3 trials, GEMINI 1 and GEMINI 2 (NCT04410978; NCT04410991), in patients with relapsing-remitting and relapsing secondary progressive MS.
The Comprehensive Management of Dravet Syndrome
November 25, 2021
Article
In a NeurologyLive® Insights series, experts in the diagnosis and treatment of Dravet syndrome discussed the management of the disease and the utilization of approved treatments to improve outcomes in patients.
NeuroVoices: Orrin Devinsky, MD, on Unanswered Questions With SUDEP, Heart Rate Variability
November 24, 2021
Article
The director of the Comprehensive Epilepsy Center at NYU Langone discussed the large-scale impact heart rate variability has on preventing SUDEP and the unanswered questions that remain.
MS Functional Connectivity Abnormalities Not Defined by One Brain Region
November 23, 2021
Article
In cognitively impaired vs unimpaired patients, investigators found functional connectivity decreases in DMNa and DMNp and increases in the right and left frontoparietal networks.
Enrollment Complete for Phase 2 Study of ATH-1017 in Moderate Alzheimer
November 23, 2021
Article
A total of 77 patients randomized to either ATH-1017 or placebo will be evaluated for improvements in cognition, global, and functional assessments across a 26-week treatment period.
Incidence of Poststroke Dementia Remains Highly Prevalent
November 23, 2021
Article
The risk of dementia was substantial and front-loaded following stroke, with the 1-year prevalence similar to the estimate for dementia at any time point. The findings indicate a need for greater engagement between stroke and dementia care.
Heart Rate Variability Identified as Potentially Crucial SUDEP Biomarker
November 22, 2021
Article
Reduced low-frequency power measured at rest was independently associated with an elevated SUDEP risk, presumably through arrhythmogenic mechanisms.
Prestroke Glycemic Control Associated With Subsequent Risk of Composite Vascular Events
November 22, 2021
Article
The optimal range of HbA1c between 6.8% and 7.0% at admission was estimated to have the minimum risk for composite vascular events and stroke recurrence, with notably different levels according to stroke subtype.
Low-Dose Lithium Shows Mixed Benefits for Alzheimer, Fails to Improve Behavioral Complications
November 21, 2021
Article
Despite not being significantly superior to placebo on agitation and aggression, lithium showed a greater reduction in those with high Young Mania Rating Scale scores.
Neflamapimod Displays Robust Efficacy in Pure Lewy Body Dementia Pathology
November 19, 2021
Article
The magnitude of neflamapimod’s effect on several efficacy measures proved to be consistent with the mechanism of action and prior preclinical data, with p-tau181 data suggesting a stronger effect on nonmixed Lewy body pathology.