Congress of the European Sleep Research Society 2018

The 24th Congress of the European Sleep Research Society was held in Basel, Switzerland, from September 25 to September 28, 2018. It brought together researchers and clinicians working in the field of sleep research and sleep medicine intent on promoting research on sleep and related areas, to improve the care for patients with sleep disorders. 
Actigraphic recording from upper extremities show consistently more prominent sleep fragmentation in rapid eye movement sleep behavior disorder patients compared to other sleep diagnoses.
The associate professor at NYU Langone discussed several of the questions that remained unanswered about the relationship between sleep and Alzheimer disease.
The associate professor at NYU Langone discussed emerging evidence that suggests that sleep disruption results in higher levels of markers associated with Alzheimer disease.
Recent work demonstrates that the anterior part of the hypothalamus is enlarged in cluster headache.
The neurologist discussed an analysis of findings suggesting that opiate agonists may have a role in the treatment of narcolepsy.
The study presents direct evidence that subjective experiences of insomnia may be coupled to the REM sleep state.
Heidbreder further described the current understanding of the condition and what she and her colleagues have found out.
The Psychiatrist at Psychiatric Services Solothurn and University of Basel discussed how heart rate variability correlates with sleep stages, which may indicate nocturnal brain activity. 
Under treatment, the dynamic of REM sleep related heart rate variability shows early changes during the first week, providing a promising biomarker of treatment.
Impairment of physiological spindle activity in the hippocampus during NREM sleep by interictal epileptic activities may have negative consequences on long-term memory consolidation.
Those suffering from significant emotional distress and sleep disturbances may benefit from targeted interventions to restore consolidated REM sleep or prevent the occurrence of fragmented REM sleep.
The postdoctoral scientist spoke about an actimetry-based method studying the clinical relevance of temporal dynamics of sleep to make the dynamics easily quantifiable in everyday context.
The medical coordinator of the Multidisciplinary Sleep-Wake Disorders Center at Antwerp University Hospital spoke about how to address some of the issues faced in OSA treatment development.
The identification of the subtypes allows future studies to target homogeneous subtype samples, resolve inconsistencies, personalize treatment and utilize preventive interventions.
Proof-of-concept studies using a targeted phenotypic approach to reduce obstructive sleep apnea severity are showing exciting results.
The identification of 3 key non-anatomical contributors to OSA has unlocked new potential pharmacotherapies, a major advance for the field.
Recent research has identified novel potential pathophysiological mechanisms that could potentially serve to subclassify various phenotypes in obstructive sleep apnea.
The actimetry-based method allows for easily quantifiable sleep dynamics in real life context, enabling large-scale clinical studies to investigate the complex temporal dynamics of sleep.
Long-term maintenance of efficacy was demonstrated with solriamfetol for treatment of excessive sleepiness with narcolepsy or obstructive sleep apnea.
The neurologist and sleep specialist spoke about data from one of many studies investigating solriamfetol for treatment of narcolepsy and obstructive sleep apnea with remaining excessive daytime sleepiness.
Chylinski spoke about the relationship between the increased number of arousals during sleep and the pathogenesis of Alzheimer disease.

About the 24th Congress of the European Sleep Research Society:

The 24th Congress of the European Sleep Research Society brings together researchers and clinicians intent on promoting research on sleep and related areas to improve the care for patients with sleep disorders. NeurologyLive offers the most up-to-date information regarding existing treatment options, as well as data from clinical trials evaluating new and emerging therapies, to those unable to travel to network with the European Sleep Research Society in Basel.
This Conference Coverage page at NeurologyLive is a full-service resource center for the latest from ESRS 2018, including key developments from research that may potentially lead to a better understanding of sleep disorder causes, methods of early diagnosis, symptom management, and prevention. It serves as a hub of information and news from the conference and includes focal coverage right from the floor.

For related content, check out NeurologyLive’s sleep medicine Condition Center page.