Managing Excessive Daytime Sleepiness in Obstructive Sleep Apnea: Diagnostic and Therapeutic Approaches

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W. Chris Winter, MD, and Margaret Park, MD, discuss how excessive daytime sleepiness in patients with obstructive sleep apnea is often underdiagnosed due to cultural normalization of fatigue and patient rationalization of symptoms, requiring clinicians to actively screen for sleepiness as a vital sign and consider FDA-approved wake-promoting medications like modafinil, armodafinil, and solriamfetol for those with residual sleepiness despite effective continuous positive airway pressure therapy.

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