Studies examined the impact of blood pressure trajectories on dementia risk and explored the relationship between sleep apnea and Aβ accumulations.
Studies presented on aging and dementia during AAN 2017 Annual Meeting looked at cerebrospinal fluid levels of tau in frontotemporal lobar degeneration, examined the impact of blood pressure trajectories in mid-life and late-life on dementia risk, and explored whether or not sleep apena affected amyloid plaque accumulation.
Do ante mortem cerebrospinal fluid (CSF) levels of tau correlate with post mortem tau pathology in frontotemporal lobar degeneration (FTLD)?
Higher CSF p-tau levels are related to higher cerebral tau burden in FTLD and detection of Alzheimer copathology in FTLD during life “may help stratify clinical cohorts with ‘pure’ neuropathology in which CSF p-tau levels may have diagnostic utility.”
While lower blood pressure in midlife was linked to cognitive benefits, data suggests lowering blood pressure in older adults may be harmful to cognition.
Sleep Apnea During NREM But Not REM Inversely Correlates with CSF Amyloid Beta 42 But Not Tau Levels