Summary for Physicians
Managing ARIA Risk in Patients Receiving Lecanemab or Donanemab
Both lecanemab and donanemab carry a boxed warning for amyloid-related imaging abnormalities (ARIA), which can manifest as edema (ARIA-E) and/or microhemorrhages or superficial siderosis (ARIA-H). While often asymptomatic, symptomatic ARIA can cause headache, confusion, dizziness, visual changes, nausea, or seizures.
Clinical Management of ARIA
1. Baseline Screening and Risk Stratification
- Baseline MRI is required prior to initiating therapy to assess for:
- Any preexisting edema or lesions
- APOE ε4 carrier status may influence ARIA risk, with higher incidence in carriers, particularly homozygotes. Testing is often recommended but not mandatory.
2. Monitoring Protocol
- Prior to the 5th, 7th, and 14th infusions (for lecanemab)
- Or as clinically indicated if symptoms arise
- Routine symptom surveillance during and between infusions (eg, headache, confusion, dizziness)
- Neurologic assessments are integrated into infusion visits to monitor for early signs of ARIA.
3. Management of Detected ARIA
- Mild cases: Often monitored without treatment interruption.
- Moderate to severe: May require temporary holding of therapy with repeat MRI monitoring.
- Therapy is held immediately.
- Supportive care provided based on symptoms (eg, corticosteroids for severe edema).
- Neurology consult and close imaging follow-up.
- Re-challenge decisions are made on a case-by-case basis after resolution.
Operational Considerations
- Multidisciplinary Coordination: Neurologists, radiologists, infusion nurses, and care navigators are key to safe delivery.
- Patient Education: Patients and caregivers are counseled on ARIA risks, symptoms to watch for, and the importance of adhering to MRI schedules.
- Documentation and Communication: Clear protocols and electronic medical record reminders support consistent risk tracking and decision-making.
Key Takeaway
Managing ARIA requires structured protocols, proactive imaging, and early symptom recognition, balancing safety with the potential benefits of amyloid-lowering therapy in early Alzheimer disease.