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ARIA With Monoclonal Antibody Treatments for Alzheimer Disease

Panelists discuss how managing ARIA risk in patients receiving lecanemab or donanemab requires structured MRI monitoring, multidisciplinary coordination, and patient education to ensure safe treatment while maximizing the benefits of amyloid-lowering therapies in early Alzheimer disease.

Summary for Physicians

Managing ARIA Risk in Patients Receiving Lecanemab or Donanemab

Both lecanemab and donanemab carry a boxed warning for amyloid-related imaging abnormalities (ARIA), which can manifest as edema (ARIA-E) and/or microhemorrhages or superficial siderosis (ARIA-H). While often asymptomatic, symptomatic ARIA can cause headache, confusion, dizziness, visual changes, nausea, or seizures.

Clinical Management of ARIA

1. Baseline Screening and Risk Stratification

  • Baseline MRI is required prior to initiating therapy to assess for:

  • Microhemorrhages

  • Siderosis

  • Any preexisting edema or lesions

  • APOE ε4 carrier status may influence ARIA risk, with higher incidence in carriers, particularly homozygotes. Testing is often recommended but not mandatory.

2. Monitoring Protocol

  • Scheduled MRIs:

  • At baseline

  • Prior to the 5th, 7th, and 14th infusions (for lecanemab)

  • Or as clinically indicated if symptoms arise

  • Routine symptom surveillance during and between infusions (eg, headache, confusion, dizziness)

  • Neurologic assessments are integrated into infusion visits to monitor for early signs of ARIA.

3. Management of Detected ARIA

  • Asymptomatic ARIA:

  • Mild cases: Often monitored without treatment interruption.

  • Moderate to severe: May require temporary holding of therapy with repeat MRI monitoring.

  • Symptomatic ARIA:

  • Therapy is held immediately.

  • Supportive care provided based on symptoms (eg, corticosteroids for severe edema).

  • Neurology consult and close imaging follow-up.

  • Re-challenge decisions are made on a case-by-case basis after resolution.

Operational Considerations

  • Multidisciplinary Coordination: Neurologists, radiologists, infusion nurses, and care navigators are key to safe delivery.

  • Patient Education: Patients and caregivers are counseled on ARIA risks, symptoms to watch for, and the importance of adhering to MRI schedules.

  • Documentation and Communication: Clear protocols and electronic medical record reminders support consistent risk tracking and decision-making.

Key Takeaway

Managing ARIA requires structured protocols, proactive imaging, and early symptom recognition, balancing safety with the potential benefits of amyloid-lowering therapy in early Alzheimer disease.

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