COMT Inhibitors Assist in Control of Parkinson Disease Motor Symptoms

NeurologyLiveFebruary 2019
Volume 2
Issue 1

More recently, investigators have discovered that catechol-O-methyltransferase inhibitors can prolong the effects of levodopa, thereby limiting the off-time phenomenon.

Parkinson disease is second only to Alzheimer disease as the most common neurodegenerative disorder in the United States, affecting more than 680,000 individuals.1 Notably, that large prevalence of Parkinson is expected to only increase as the population ages, estimated to affect more than 1 million Americans by 2030.2

The motor dysfunction associated with Parkinson is the result of the degeneration of dopamine neurons in the substantia nigra. One method to restore dopamine in the brain is to administer levodopa, a precursor of dopamine that can cross the blood-brain barrier and be converted into dopamine.

As dopaminergic cell loss becomes more advanced with disease progression, the associated motor symptoms often interfere with an individual’s ability to perform everyday activities, resulting in an inability to maintain control over motor symptoms that can negatively affect a patient’s quality of life.

Indeed, levodopa is the best available treatment for managing Parkinson motor symptoms. Although, a major drawback of this well-established medication is the fluctuation in its effectiveness. This common complication is known as off time, as it typically occurs toward the end of a dose, when levodopa is wearing off, and is defined by the reappearance of symptoms.3

The traditional strategy to prevent off time is to modify the dosage of levodopa; however, this often leads to exacerbation of unwanted adverse effects, such as dyskinesia and increased difficulties with treatment adherence. More recently, though, investigators have discovered that catechol-O-methyltransferase (COMT) inhibitors can prolong the effects of levodopa, thereby limiting the off-time phenomenon.4

Role of COMT in Parkinson

“COMT inhibitors play an important role in modifying the pharmacokinetics of levodopa,” stated Werner Poewe, MD, the director of the Department of Neurology at the Medical University of Innsbruck in Austria, at the 2016 German Society of Neurology (DGN) Congress in Mannheim, Germany.4

COMT is an enzyme that eliminates levodopa by catalyzing the conversion of levodopa to 3-O-methyldopa, a metabolite that has no known therapeutic value. COMT inhibitors block this metabolic pathway in the periphery, thereby increasing the amount of levodopa that is available to be converted into dopamine (see FIGURE).

As a result of this process, COMT inhibitors enhance the therapeutic effect of levodopa by increasing its bioavailability and sustainability, thus preventing wearing off and improving clinical responsiveness.5 Importantly, COMT inhibitors have no direct effect on Parkinson symptoms, so they are effective only when administered in combination with levodopa.

COMT pathway in the brain.

Approved COMT Inhibitors

Current FDA-approved COMT inhibition therapies include tolcapone (Tasmar; Valeant Pharmaceuticals) and entacapone (Comtan; Novartis). Both medications are indicated to treat the end-of-dose wearing off of levodopa in patients with Parkinson.6,7

Entacapone is recommended as first-line treatment, whereas tolcapone is recommended as a second-line treatment because of liver toxicity adverse effects (AEs).8 More recently, a combination pill of entacapone, levodopa, and carbidopa (Stalevo; Novartis) was approved for the treatment of Parkinson in the United States.9

Tolcapone was approved for use by the FDA in 1997 based on clinical trials that demonstrated its ability to significantly reduce time in the off state (ie, reduce wearing-off complications) compared with placebo.11,12 Unfortunately, tolcapone treatment was associated with elevations in liver enzymes, suggesting that its use may lead to liver toxicity.

As a result, its FDA approval was contingent on mandatory liver function monitoring during tolcapone treatment.7 Results from post­marketing surveillance studies revealed that tolcapone treatment had been associated with 3 cases of fatal hepatoxicity and 1 case of severe liver injury. As such, tolcapone is currently recommended as a second-line treatment option for patients who have not responded to other adjunc­tive therapies.12,13

Entacapone was then approved for use by the agency in 1999. The efficacy and safety of entaca­pone were established in a series of clinical trials, which demonstrated that entacapone signifi­cantly reduced the amount of time in the off state compared with placebo.6,14 Recent studies and meta-analyses estimate that entacapone reduces off episodes by an average of 40 minutes.15,16 Although results from studies have shown the clinical efficacy of enta­capone to be inferior to tolcapone, the safety profile of entacapone has improved.17,18

The most common adverse effects associated with entacapone include nausea, urine discoloration, gastrointestinal disorders, and dyskinesia.6,19 Importantly, entacapone is not associated with hepatic dysfunction, so liver monitoring is not required during enta­capone treatment.

Ultimately, entacapone is a favorable treatment alternative to tolca­pone because of its superior safety profile. However, although enta­capone is a well-tolerated COMT inhibitor, it must be taken concom­itantly with each dose of levodopa, which can result in dosing up to 8 times per day, in addition to levodopa dosing.6

A more convenient treatment regimen is, as noted, now available with the combination levodopa/ entacapone/carbidopa pill.9 The safety and efficacy of this combination pill were established in 2 clinical trials. In the FIRST-STEP trial (NCT00134966), the triad combination was found to significantly reduce time in the off state without increasing dyskinesia compared with just levodopa/ carbidopa treatment.20

Interestingly, although the FIRST-STEP trial did not find an increase in dyskinesia with the combination pill, the STRIDE-PD trial did find that the levodopa/ entacapone/carbidopa amalgamation worsened dyskinesia AEs.21 Nonetheless, the combination pill has been found to be effective and reduces the number of pills that must be taken each day, providing a more convenient option for patients.

In the clinic, entacapone is the common first-line treatment strategy for Parkinson motor symptoms; however, it only moderately reduces time in the off state and must be taken with each levodopa dose. Tolcapone is more efficacious than entacapone, but its use is limited because of liver toxicity adverse effects.

“Thus, a more effective COMT inhibitor that can be easily used in routine clinical practice is needed,” stated Joaquim J. Ferreira, MD, from the University of Lisbon in Portugal, in Lancet Neurology.16

COMT Inhibitors in Development

Opicapone (Ongentys; Neurocrine Biosciences) is a novel, once-daily COMT inhibitor that was approved for use in Europe in 2016 based on the results of 2 clinical trials, BIPARKI and BIPARKII.22 It is currently under development for use in the United States.

The safety and efficacy of opicapone were established in the afore­mentioned randomized, double-blind, placebo-controlled phase 3 clinical trials.23-25 In the BIPARKI trial, opicapone was compared with placebo and entacapone in 600 patients with Parkinson disease. Opicapone was found to be superior to placebo and equivalent to enta­capone at reducing time in the off state. Specifically, it was estimated that opicapone reduced off episodes by an average of 60 minutes.

Compared with the estimated 40-minute reduction with entaca­pone, this suggests that opicapone may have a greater magnitude of the effect. Importantly, these results were found for a once-daily dose of opicapone, establishing it as the first-ever COMT inhibitor that allows once-daily dosing.23,24

The BIPARKII trial validated that once-daily opica­pone is well tolerated and more effective at reducing end-of-dose wearing off than placebo.24 Further, both trials demonstrated that the effects of opica­pone were maintained for 1 year, during which the levodopa dose was not increased.

The most common AEs associated with opica­pone treatment included dyskinesia, constipa­tion, and dry mouth.

“The simplicity afforded by the once-daily administration means that addition of this drug will not further complicate the patients’ current drug regimen,” stated Andrew J. Lees, MD, from the University College London in England, in JAMA Neurology.23

“When combined with the favorable safety and tolerability profile, these characteristics position opicapone as a strong candidate for the adjunct treatment of motor fluctuations in Parkinson,” Lees and colleagues concluded.23

What’s Next

In 2017, Neurocrine Biosciences announced that it would be responsible for developing and commercializing opicapone in the United States.26 After the manufacturer met with the FDA in 2017 to discuss a new drug application, the agency did not request that additional phase 3 clinical trials be conducted.

As a result, Neurocrine Biosciences stated it hopes to begin the regulatory review process of opicapone in early 2019.26 It is, therefore, possible that opicapone may be approved in the United States as a novel once-daily COMT inhibitor treatment for Parkinson motor symptoms in the near future.

“When thinking on the switch from entacapone to opicapone, patients should be closely monitored for development of dyskinesia; however, patients switching to opicapone will not show signs of urine discoloration, as would be the case with entacapone,” Thomas Müller, MD, head of the Department of Neurology at St. Joseph Hospital in Berlin, Germany, stated at the 2016 DGN Congress in Mannheim, Germany.4 “On the other hand, patients on opicapone have no need for liver monitoring, as is the case with tolcapone.

“In general, treatment changes should only be made if a patient is dissatisfied with their current treatment,” Müller concluded.4


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21. Stocchi F, Rascol O, Kieburtz K, et al. Initiating levodopa/carbidopa therapy with and without entacapone in early Parkinson disease: the STRIDE-PD study [erratum in Ann Neurol. 2010;68(3):412-413]. Ann Neurol. 2010;68(1):18-27.


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. Updated February 2, 2017. Accessed January 19, 2019. Pipeline: clinical trials. Neurocrine Biosciences website. Accessed January 19, 2019.

26. Neurocrine


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