Opinion
Video
Defining Rapid and Early Seizure Termination (REST) in Epilepsy
Author(s):
A panelist discusses how REST empowers patients and caregivers to intervene at seizure onset with fast-acting rescue therapies, preventing escalation, reducing emergency care, and improving long-term outcomes and quality of life.
Summary for Physicians:
Rapid and Early Seizure Termination (REST):
The concept of REST refers to the timely intervention at the onset of a seizure using fast-acting, accessible treatments—typically benzodiazepine rescue medications—to stop seizures quickly before they become prolonged or progress to status epilepticus.
Clinical Value of REST in Seizure Management:
- Prevents Seizure Escalation: Prompt treatment at the first signs of a seizure can prevent the event from becoming prolonged or evolving into status epilepticus, which carries a higher risk of morbidity and mortality.
- Reduces Need for Emergency Care: Effective at-home or out-of-hospital intervention can significantly reduce emergency department visits, hospitalizations, and the burden on emergency services.
- Improves Patient Outcomes: Early termination helps preserve neurological function, reduces seizure-related injury, and can decrease the overall seizure burden over time.
- Enhances Quality of Life: Empowering patients and caregivers with tools to act quickly improves sense of control, reduces anxiety, and supports more independent living.
Implementing REST in Practice:
REST relies on early recognition of seizure patterns, access to appropriate rescue medications, and caregiver or patient education on when and how to administer treatment. Personalized seizure action plans are essential to ensure REST is applied effectively and safely.
