Defining 'Typical' and 'Atypical' Variants of CIDP

EP: 1.An Overview of CIDP

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EP: 2.Defining 'Typical' and 'Atypical' Variants of CIDP

EP: 3.Diagnosing CIDP

EP: 4.Red Flag Symptoms of CIDP

EP: 5.Current Treatment Landscape of CIDP

EP: 6.Effects on Quality of Life and Unmet Needs of CIDP

EP: 7.Emerging Agents for Treatment of CIDP

EP: 8.Clinical Pearls for HCPs Diagnosing CIDP

This is a video synopsis/summary of a panel discussion involving Richard Lewis, MD.

The speaker discusses various clinical variants of chronic inflammatory demyelinating polyneuropathy (CIDP). The typical CIDP, representing the majority of cases, is characterized by symmetric proximal and distal weakness involving shoulder, hip, hand, and ankle muscles. This progression lasts for more than eight weeks, and patients lose virtually all reflexes. The Koski criteria from over a decade ago confirmed CIDP based on clinical presentation, emphasizing the importance of nerve conduction studies.

The transcript details other CIDP variants, including the distal variant, which presents with sensory involvement and weakness at ankles and hands. The speaker highlights challenges in differentiating CIDP from conditions like idiopathic neuropathies and diabetic neuropathies, emphasizing the importance of accurate nerve conduction studies.

Other variants discussed include pure motor CIDP, pure sensory CIDP (now termed sensory-predominant CIDP), multifocal CIDP (or Lewis-Sumner Syndrome), and focal CIDP, each with distinct clinical characteristics. The speaker underscores the rarity of some variants and recommends the new guidelines for a detailed understanding, including a tailored workup for investigating potential mimics of these disorders.

Video synopsis is AI-generated and reviewed by HCPLive editorial staff.