The theme issue for the International Journal of Multiple Sclerosis Care (IJMSC) was curated by Daniel Ontaneda, MD, PhD, staff neurologist at the Cleveland Clinic and professor of neurology at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The 6 invited, peer-reviewed editorials cover comprehensive multiple sclerosis (MS) care around the globe. Though many scientific advancements have been made in caring for people with MS and each area has made strides, there remains much work to be done. The twin struggles are access and quality, frequently ebbing and flowing so that as one improves the other wanes.