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Interesting Neuro: Alzheimer Updates & PFO Device

November news includes potential Alzheimer treatments, FDA approval of a device to prevent recurrent stroke, & a newly typified headache disorder.

We present a selection of interesting neurology articles for the month of November in the following slides. See the slide legends for links to the article summaries.

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Interesting Neurology: Alzheimer Updates & PFO Device. November 2016

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The BACE1 Inhibitor Verubecestat (MK-8931) Reduces CNS β-Amyloid in Animal Models and in Alzheimer’s Disease Patients. Abstract link. **** Association of Higher Cortical Amyloid Burden with Loneliness in Cognitively Normal Older Adults. Abstract link.

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Two Novel Loci, COBL and SLC10A2, for Alzheimer's Disease in African Americans. Abstract link. ****Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Abstract Link.

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Estimating Risk of Word-Finding Problems in Adults Undergoing Epilepsy Surgery. Abstract Link. ****Long-Term Treatment of Epilepsy with Everolimus in Tuberous Sclerosis. Abstract link.

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Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine. Abstract link.****Presenting a New, Non-Hormonally Mediated Cyclic Headache in Women: End-Menstrual Migraine. Abstract link.

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Targeting Non-Classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis. Abstract link. ****Higher Latitude Is Significantly Associated with an Earlier Age of Disease Onset in Multiple Sclerosis. Abstract link.

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Sleep Problems and Hypothalamic Dopamine D3 Receptor Availability in Parkinson Disease. Abstract link.****Multifocal Repetitive TMS for Motor and Mood Symptoms of Parkinson Disease. Abstract link.

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FDA Approves New Device for Prevention of Recurrent Strokes in Certain Patients. Press release. ****Yield of Screening for Atrial Fibrillation in Primary Care with a Hand-Held, Single-Lead Electrocardiogram Device during Influenza Vaccination. Abstract link.

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Variants of Rab GTPase–Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke. Abstract link.****Folic Acid Therapy Reduces the First Stroke Risk Associated with Hypercholesterolemia among Hypertensive Patients. Abstract link.

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Metabolomics Profiling of Concussion in Adolescent Male Hockey Players: a Novel Diagnostic Method. Abstract link.****Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells. Abstract link.

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