November news includes potential Alzheimer treatments, FDA approval of a device to prevent recurrent stroke, & a newly typified headache disorder.
We present a selection of interesting neurology articles for the month of November in the following slides. See the slide legends for links to the article summaries.
Interesting Neurology: Alzheimer Updates & PFO Device. November 2016
The BACE1 Inhibitor Verubecestat (MK-8931) Reduces CNS Î²-Amyloid in Animal Models and in Alzheimer’s Disease Patients. Abstract link. **** Association of Higher Cortical Amyloid Burden with Loneliness in Cognitively Normal Older Adults. Abstract link.
Two Novel Loci, COBL and SLC10A2, for Alzheimer's Disease in African Americans. Abstract link. ****Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Abstract Link.
Estimating Risk of Word-Finding Problems in Adults Undergoing Epilepsy Surgery. Abstract Link. ****Long-Term Treatment of Epilepsy with Everolimus in Tuberous Sclerosis. Abstract link.
Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine. Abstract link.****Presenting a New, Non-Hormonally Mediated Cyclic Headache in Women: End-Menstrual Migraine. Abstract link.
Targeting Non-Classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis. Abstract link. ****Higher Latitude Is Significantly Associated with an Earlier Age of Disease Onset in Multiple Sclerosis. Abstract link.
Sleep Problems and Hypothalamic Dopamine D3 Receptor Availability in Parkinson Disease. Abstract link.****Multifocal Repetitive TMS for Motor and Mood Symptoms of Parkinson Disease. Abstract link.
FDA Approves New Device for Prevention of Recurrent Strokes in Certain Patients. Press release. ****Yield of Screening for Atrial Fibrillation in Primary Care with a Hand-Held, Single-Lead Electrocardiogram Device during Influenza Vaccination. Abstract link.
Variants of Rab GTPaseâEffector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke. Abstract link.****Folic Acid Therapy Reduces the First Stroke Risk Associated with Hypercholesterolemia among Hypertensive Patients. Abstract link.
Metabolomics Profiling of Concussion in Adolescent Male Hockey Players: a Novel Diagnostic Method. Abstract link.****Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells. Abstract link.