November news includes the first human clinical trial focusing on tau in Alzheimer disease and Zika-related microcephaly not presenting at birth.
We present a selection of interesting neurology articles for the month of December in the following slides. See the slide legends for links to the article summaries.
Autopsy Validation of 123I-FP-CIT Dopaminergic Neuroimaging for the Diagnosis of DLB. Abstract link. **** Mortality in the United States, 2015. CDC report.
Safety and Immunogenicity of the Tau Vaccine AADvac1 in Patients with Alzheimer’s Disease: a Randomised, Double-Blind, Placebo-Controlled, Phase 1 Trial. Abstract link. ****Risk of Mortality Associated with Antipsychotic Monotherapy and Polypharmacy among Community-Dwelling Persons with Alzheimer’s Disease. Abstract link.
Brain Microbiota Disruption within Inflammatory Demyelinating Lesions in Multiple Sclerosis. Abstract link. ****Cardiac Safety Profile of First Dose of Fingolimod for Relapsing-Remitting Multiple Sclerosis in Real-World Settings: Data from a German Prospective Multi-Center Observational Study. Abstract link.
Clinical Variables and Biomarkers in Prediction of Cognitive Impairment in Patients with Newly Diagnosed Parkinson’s Disease: a Cohort Study. Abstract link. ****Mitochondrial Pyruvate Carrier Regulates Autophagy, Inflammation, and Neurodegeneration in Experimental Models of Parkinson’s Disease. Abstract link.
Endovascular Treatment Improves Cognition after Stroke. Abstract link. ****Blood Pressure Levels and the Risk of Intracerebral Hemorrhage after Ischemic Stroke. Abstract link.
Preparing the United States for Zika Virus: Pre-Emptive Vector Control and Personal Protection. Abstract link. ****Description of 13 Infants Born During October 2015âJanuary 2016 with Congenital Zika Virus Infection without Microcephaly at Birth - Brazil. CDC report.