The clinical research director of the UCSF Multiple Sclerosis Center talked about a clinical trial highlighting the therapeutic benefits of longterm treatment with inebilizumab in patients with NMOSD. [WATCH TIME: 4 minutes]
WATCH TIME: 4 minutes
“This data is important because it gives us information about long term therapeutic outcomes with inebilizumab versus no treatment. It also gives us a benchmark over what has been the standard of care therapy. It will be empirically based for many years in NMO (neuromyelitis optica) and gives us a sense of the superiority and added benefit of the modern medicine inebilizumab compared to azathioprine. Together, this provides us a wealth of information.”
Neuromyelitis optica spectrum disorder (NMOSD) is a rare sever autoimmune disease characterized by acute inflammatory attacks afflicting the central nervous system. The FDA-approved treatments for patients with aquaporin-4-IgG-seropositive (AQP4 IgG+) NMOSD include eculizumab (Soliris; Alexion), inebilizumab (Uplizna; Horizon Therapeutics), and satralizumab (Enspryng; Genentech). Inebilizumab’s approval was based on the N-MOmentum trial (NCT02200770), a randomized placebo-controlled trial lasting 6 months.1 Off label therapies including immunosuppressants such as azathioprine and mycophenolate mofetil have been used to treat the disease as well.
At the 2023 MSMilan, the 9th Joint ECTRIMS-ACTRIMS meeting, October 11–13, in Milan, Italy, lead author Bruce Cree, MD, PhD, MAS, FAAN, the clinical research director of the UCSF Multiple Sclerosis Center, presented efficacy data on a subpopulation of patients from the open-label extension of N-MOmentum, comparing the treatment with azathioprine, immunosuppressants, and placebo. In this study, inebilizumab treatment was associated with a statistically significant reduction in risk of an attack compared with the other commonly used treatments and those with no treatment.1
At the meeting, Cree sat down in an interview with NeurologyLive® to discuss biomarker progress in NMOSD, clinical management, and silent progression of the neurological disease. He talked about how N-Momentum managed to minimize placebo exposure while assessing the effects of inebilizumab in patients with NMOSD. Also, Cree spoke about the key findings when comparing inebilizumab with a placebo and azathioprine over a 4-year period, as well as explained how ibalizumab's therapeutic benefits improve with each subsequent treatment.