Too many-or too few-pounds-could be a factor in migraine pathogenesis. Details here.
Too many-or too few-pounds-could be a factor in migraine pathogenesis. Scroll through the slides for details.
What’s BMI, Age, and Gender Got to Do with it?
. Migraine risk is increased in both obese and underweight individuals, according to a new study.1
. Age and gender appear to be important covariates of this association.
>A look at the association between migraine and body composition
. A meta-analysis of 12 studies with 288,981 participants evaluated the association between migraine and body composition.
. In 2 studies, most of the participants were aged 50 or older. Other studies included mostly younger participants.
. In half of the studies Participants self-reported migraine in half the studies
. Participants self-reported their BMI in more than half the studies
Shed or gain a few lbs?
After adjustments for age and sex, obese people (BMI >30) were 27% more likely to have migraine than people of normal weight.
Those who were underweight (BMI <18.5) were 13% more likely to have migraine than people of normal weight.
Age- and sex-adjusted pooled migraine risk was increased in overweight people. This association was lost after adjustment.
. In underweight people, the age- and sex-adjusted pooled risk of migraine increased by 13% vs with normal weight people.
Adipose tissue a migraine trigger?
. Body composition could affect migraine through adipose tissue, which secretes a wide range of molecules that potentially play a role in developing or triggering migraine.
. Other factors could include changes in physical activity, medications, or conditions such as depression.
Clinical implications for your practice.
. Increased migraine risk is moderate, along the lines of the association of ischemic heart disease and bipolar disorders and body weight.
. Since both obesity and being underweight are potentially modifiable risk factors for migraine, clinicians should be more aware of the body weight of their migraine patients.
. More research is needed to determine whether losing or gaining weight lowers the risk for migraine.