Recent Advances and Emerging Therapies in the Management of Alzheimer Disease


In this episode of MEDcast, expert geriatric psychiatrist and neurologist delve into the recent advances in the treatment of Alzheimer’s disease. We will discuss treatments that are on the cusp of FDA approval and others that are coming down the pipeline.

0:00 Introduction

1:25 An overview of the current standard of care in of Alzheimer’s disease

4:55 Pathophysiology of Alzheimer’s disease

6:58 Aducanumab and lecanemab for Alzheimer’s disease

9:45 Mechanism of action of anti-amyloid agents

11:19 Leaky cell theory in Alzheimer's disease

12:35 Efficacy and safety of aducanumab and lecanemab

13:26 Safety of emerging agents in Alzheimer’s disease

16:37 Practical implementation of lecanemab

19:23 Challenges in CMS coverage for treatments of Alzheimer’s

24:05 Efficacy and safety of Donanemab

25:35 Overcoming clinical inertia around emerging agents in Alzheimer’s disease

29:30 A look into the future of management of Alzheimer’s disease

31:30 Summary

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