Marco Meglio, Editor for NeurologyLive, has been with the team since October 2019. Follow him on Twitter @marcomeglio1 or email him at firstname.lastname@example.org
Increased Tau Burden Observed in Abnormal Central Vascular Hemodynamics
Patients who demonstrated increased central pulse pressure and forward wave amplitude had greater entorhinal tau burden. These measures were not associated with amygdala, inferior temporal, nor precuneus tau burden.
Cognitive Training With Constant Therapy Shows Feasibility in Early-Stage Alzheimer Disease
Long-term use of the Constant Therapy program was feasible in a patient population with Alzheimer disease, as shown by the rate of adherence (80%) and use of the program over 24 weeks.
NeuroVoices: Lynn Bekris, PhD, on Future Research for sTREM2, GFAP, and Immunotherapies in Alzheimer Disease
The molecular biologist at the Cleveland Clinic Lerner Research Institute discussed the unanswered questions regarding biomarkers sTREM2 and GFAP, and the role they play in Alzheimer pathology.
LIFT-AD Study Amended to Assess Alzheimer Disease Agent Fosgonimeton as Monotherapy
In a previous phase 2 study, patients treated with fosgonimeton alone demonstrated potentially beneficial change in ERP P300 latency, as well as cognitive improvement, compared with placebo at 26 weeks.
Levodopa Pump Agents Show Feasibility in Pharmacokinetic Study of Parkinson Disease
Infudopa SubC, or subcutaneous DIZ102, demonstrated 100% bioavailability compared with 80% for intestinal administration of levodopa/carbidopa gel infusion.
Long-Term Use of Diazepam Nasal Spray Improves Time Between Seizure Clusters
A doubling of mean seizure intervals was demonstrated from period 1 to period 4 for the 76-patient cohort who received the Neurelis nasal spray treatment across 360 days.
Using Virtual Reality and Changes in Activities of Daily Living to Expose Prodromal Signs of Parkinson Disease
Jay Alberts, PhD, the Edward F. and Barbara A. Bell Endowed Chair at Cleveland Clinic, provided commentary on an innovative approach using virtual reality to detect early signs of Parkinson disease.
Somatic Symptom Disorder Identified as Neurological Outcome of Long COVID-19
Using patients with post–COVID-19 neurological symptoms, 90% of the cohort fulfilled the criteria for chronic fatigue syndrome, as expressed by the SOFA scale.
FDA Advisory Committee Votes to Recommend AMX0035 for Treatment of ALS
If approved, the oral fixed-dose coformulation of sodium phenylbutyrate-taurursodiol will become the third medication to receive an FDA greenlight for ALS.
Philips Respironics Recalls Masks for BPAP and CPAP Machines After Safety Concerns
In a recently submitted medical device report, Philips reported 14 serious injuries and 0 deaths related to the use of the recalled masks.
Multiple Sclerosis Immune Responses to COVID-19 Vaccinations to Be Evaluated in COVER-MS Project Substudy
The substudy of the COVER-MS Project includes 300 patients with multiple sclerosis and will harness Quest Diagnostic’s national network of more than 2100 patient centers to provide periodic blood samples of immune responses to COVID-19 vaccines.
NeuroVoices: Lynn Bekris, PhD, on sTREM2 and GFAP to Differentiate Cognitive Status, Trajectory
The molecular biologist at the Cleveland Clinic Lerner Research Institute provided commentary on how certain activity markers may help understand immune response differences in Alzheimer disease and related dementias.
Stenting for Symptomatic Severe Intracranial Atherosclerotic Stenosis Does Not Improve Odds of Stroke, Death
Despite efforts to reduce perioperative complications rates by vetting of surgeons and sites, and refining patient selection, the findings nonetheless demonstrated no clinical benefit from the addition of stenting to medical therapy.
Impaired Sleep, Subclinical Insomnia More Common During COVID-19 Pandemic
Stringent governmental measures predicted lower global scores on Pittsburgh Sleep Quality Index, while, albeit to a small extent, less restrictive measures were related to worse subjective sleep quality.
Atrial Fibrillation Screening With Implantable Loop Recorder Fails to Significantly Reduce Stroke Risk
Among controls, there was a statistically significant difference of modified Rankin Scale scores between patients with and without atrial fibrillation, whereas no statistical difference was observed in the implantable loop recorder group.
Migraine Medication Rimegepant Shows Significant Ability to Lower Barbiturate Use
Treatment with rimegepant, an FDA-approved treatment for acute and preventative migraine, resulted in decreases of more than 30% in monthly butalbital prescription fill and reductions of more than 25% in mean milligrams dispensed.
Vamorolone Shows Efficacy in Duchenne Muscular Dystrophy, Safety Advantages Over Prednisone
Compared with placebo, vamorolone-treated patients showed significantly better outcomes on several secondary and exploratory end points, such as the NorthStar Ambulatory Assessment and time to climb 4 stairs.
Timing of Physical Activity Affects Its Benefit for Restless Legs Syndrome in Multiple Sclerosis
Evening physical activity was associated with lower restless legs syndrome severity, while more time spent in the morning on physical activity, specifically light physical activity, was associated with worse sleep quality.
Behavioral Impairments More Commonly Found in SOD1 ALS Than Cognitive Impairments
Using Strong et al’s classification criteria, the percentage of SOD1+ and SOD1- patients with altered cognitive and/or behavioral profiles were similar; however, cognitive and behavioral impairment differentiated between groups.
DNL310 Shows Sustained Reductions of Hunter Syndrome Biomarkers in CNS and Periphery
After switching from idursulfase to Denali’s DNL310, patients demonstrated mean declines of more than 80% for both heparan sulfate and dermatan sulfate biomarkers at week 49 of treatment.
Phase 2 Results Highlight Milvexian's Potential to Reduce Stroke Risk
Milvexian at doses of 25 mg to 100 mg twice daily showed an approximate 30% relative risk reduction of ischemic stroke compared with placebo.
Combination of PTSD and Insomnia Elevates Risk for Major Cardiovascular Events
Even after adjusting for multiple confounding variables including recognized factors associated with cardiovascular diseases, PTSD plus insomnia remained an independent factor of major adverse cardiovascular events.
Repetitive Transcranial Magnetic Stimulation Shows Effectiveness in Treating Excessive Daytime Sleepiness in Parkinson Disease
In comparison to nonresponders, those in the active treatment group who did respond well exhibited longer disease duration and lower baseline levodopa equivalent dose.
NeuroVoices: Paul Lipkin, MD, on Improved CDC Guidelines for Developmental Milestones
The director of medical outpatient services at the Kennedy Krieger Institute discussed the changes and implications of new CDC guidelines on developmental milestones for growing children.
Causative and Unknown Etiology MRI Abnormalities Both Common in Newly Diagnosed Focal Epilepsy
Younger patients were more likely to have epilepsy-related imaging abnormalities, while older patients were more likely to have incidental abnormalities or those with an unknown relationship to epilepsy.
Penumbra System and RED Reperfusion Catheter Effectively Treat Acute Ischemic Stroke, Remove Clot Types
In a subanalysis of individuals with acute ischemic stroke with tandem lesions, treatment with the Penumbra system resulted in successful revascularization in almost 90% of patients.
Early Tobacco Use in Children Leads to Poorer Cognitive Performance, Reduced Brain Structure
Those who had used tobacco at any time demonstrated multiple significantly lower whole-brain measures than nonusers, including total cortical surface area, cortical volume, and total intracranial volume.
Brain Atrophy Patterns Similar in Parkinson Disease Regardless of Brain- or Body-First Marker Changes
Results showed significantly smaller bilaterally gray matter volumes in Parkinson disease compared with controls, but no differences in brain-first or body-first subtypes on asymmetric atrophy.
Increased GFAP Concentration First Observed in Presymptomatic Stages of Familial Alzheimer Disease, With Rises Over Time
Plasma GFAP was increased in both presymptomatic and symptomatic mutation carriers compared with noncarriers, and in symptomatic compared with presymptomatic carriers.
Zoom Stroke Solution Shows Continued Efficacy in Treating Distal Occlusions of Ischemic Stroke
For patients with MCA M2 occlusions, use of the Zoom Stroke Solution resulted in significant decreases in National Institutes of Health Stroke Scale scores and no reported perforations or other reperfusion–catheter-related complications.
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