Marco Meglio, Editor for NeurologyLive, has been with the team since October 2019. Follow him on Twitter @marcomeglio1 or email him at mmeglio@neurologylive.com
Increased Tau Burden Observed in Abnormal Central Vascular Hemodynamics
September 15th 2022Patients who demonstrated increased central pulse pressure and forward wave amplitude had greater entorhinal tau burden. These measures were not associated with amygdala, inferior temporal, nor precuneus tau burden.
LIFT-AD Study Amended to Assess Alzheimer Disease Agent Fosgonimeton as Monotherapy
September 13th 2022In a previous phase 2 study, patients treated with fosgonimeton alone demonstrated potentially beneficial change in ERP P300 latency, as well as cognitive improvement, compared with placebo at 26 weeks.
NeuroVoices: Lynn Bekris, PhD, on sTREM2 and GFAP to Differentiate Cognitive Status, Trajectory
September 7th 2022The molecular biologist at the Cleveland Clinic Lerner Research Institute provided commentary on how certain activity markers may help understand immune response differences in Alzheimer disease and related dementias.
Migraine Medication Rimegepant Shows Significant Ability to Lower Barbiturate Use
September 4th 2022Treatment with rimegepant, an FDA-approved treatment for acute and preventative migraine, resulted in decreases of more than 30% in monthly butalbital prescription fill and reductions of more than 25% in mean milligrams dispensed.
Vamorolone Shows Efficacy in Duchenne Muscular Dystrophy, Safety Advantages Over Prednisone
September 3rd 2022Compared with placebo, vamorolone-treated patients showed significantly better outcomes on several secondary and exploratory end points, such as the NorthStar Ambulatory Assessment and time to climb 4 stairs.
Timing of Physical Activity Affects Its Benefit for Restless Legs Syndrome in Multiple Sclerosis
September 2nd 2022Evening physical activity was associated with lower restless legs syndrome severity, while more time spent in the morning on physical activity, specifically light physical activity, was associated with worse sleep quality.
Behavioral Impairments More Commonly Found in SOD1 ALS Than Cognitive Impairments
September 2nd 2022Using Strong et al’s classification criteria, the percentage of SOD1+ and SOD1- patients with altered cognitive and/or behavioral profiles were similar; however, cognitive and behavioral impairment differentiated between groups.
Combination of PTSD and Insomnia Elevates Risk for Major Cardiovascular Events
August 31st 2022Even after adjusting for multiple confounding variables including recognized factors associated with cardiovascular diseases, PTSD plus insomnia remained an independent factor of major adverse cardiovascular events.
Causative and Unknown Etiology MRI Abnormalities Both Common in Newly Diagnosed Focal Epilepsy
August 30th 2022Younger patients were more likely to have epilepsy-related imaging abnormalities, while older patients were more likely to have incidental abnormalities or those with an unknown relationship to epilepsy.
Early Tobacco Use in Children Leads to Poorer Cognitive Performance, Reduced Brain Structure
August 29th 2022Those who had used tobacco at any time demonstrated multiple significantly lower whole-brain measures than nonusers, including total cortical surface area, cortical volume, and total intracranial volume.
Zoom Stroke Solution Shows Continued Efficacy in Treating Distal Occlusions of Ischemic Stroke
August 27th 2022For patients with MCA M2 occlusions, use of the Zoom Stroke Solution resulted in significant decreases in National Institutes of Health Stroke Scale scores and no reported perforations or other reperfusion–catheter-related complications.