Marco Meglio, Editor for NeurologyLive, has been with the team since October 2019. Follow him on Twitter @marcomeglio1 or email him at firstname.lastname@example.org
Researchers Identify Association Between Physical Activity and Spinal Cord Gray Matter Area in Multiple Sclerosis
Findings showed that greater average daily step count was significantly correlated with greater C2-C3 spinal cord gray matter areas, total cord area, and cortical gray matter volume.
FDA Grants Fast Track Designation for Atrial Fibrillation Therapy Asundexian
Asudexian is currently being assessed in a large-scale phase 3 program expected to comprise more than 27,000 patients with atrial fibrillation across over 40 countries.
Lacosamide Provides Benefit as Second-Line Treatment for Refractory Trigeminal Neuralgia
To date, in the largest series of patients treated with lacosamide after first-line treatment failure, pain relief was achieved in 66% of patients, with a relatively low proportion of mild adverse events.
Potential Path for Phase 3 Study of AOC 1001 in Myotonic Dystrophy Becomes Clear After FDA Ease’s Clinical Hold
The phase 1/2 MARINA trial assessed the activity of AOC 1001 across key biomarkers, including spliceopathy, an important biomarker for myotonic dystrophy type 1, and knockdown of DMPK mRNA.
Full Phase 3 KINECT-HD Data Reinforces Valbenazine's Benefit in Huntington Disease Chorea
Treatment with valbenazine at doses of up to 80 mg once per day significantly improved chorea, as demonstrated by the mean change in UHDRS Total Maximal Chorea scores.
Episode 89: Potential of CNM-Au8 Gold Nanocrystals to Treat ALS
Mind Moments®, a podcast from NeurologyLive®, brings you an exclusive interview with James Berry, MD, PhD. [LISTEN TIME: 14 minutes]
Alzheimer Agent COYA 301 Halts Cognitive Decline, Restores Regulatory T Cell Dysfunction in Phase 1 Study
Over a 4-month treatment period, the agent was well tolerated, with patients showing no significant changes in ADAS-Cog or CDR-SB scores, indicating no cognitive decline.
FDA Approves Abbott’s Spinal Cord Stimulation Systems for Chronic Back Pain
Comprised of the recharge-free Proclaim SCS family and the rechargeable Eterna SCS platform, the approval for Abbott’s spinal cord stimulation system was backed by the large-scale, DISTINCT study.
Phase 2 Data Highlight Fenebrutinib’s Impact on Brain Lesions in Relapsing Multiple Sclerosis
Findings from the 12-week study showed a significant decrease in total number of new gadolinium-enhancing lesions in patients with relapsing MS on fenebrutinib relative to placebo.
Robotic Thymectomy Safe and Effective in AChR-Myasthenia Gravis Regardless of Thymomatous Status
Following thymectomy, more than 80% of patients with myasthenia gravis showed symptom improvement, as demonstrated by changes in Myasthenia Gravis Foundation of America scores.
NeuroVoices: Nancy Foldvary-Schaefer, DO, FAAN, on the Crossover Between Sleep and Epilepsy
The director of the Sleep Disorders Center and staff in the Epilepsy Center at Cleveland Clinic provided perspective on the current state of sleep and epilepsy research, including the role of postical generalized EEG suppression as a biomarker for SUDEP.
Soticlestat Decreases Motor Frequency in CDKL5 Deficiency Disorder, With Benefits in Dup15q Syndrome
Improvements seen in patients with CDD during the 12-week maintenance period of the study were similar to that observed in a recent trial of ganaxolone, the first FDA-approved therapy for CDD.
Higher Vascular Risk Indirectly Predicts Lower Plasma Aß42/40 in APOE ɛ4 Carriers
Regardless of highly different demographics and smaller sample size, the association between amyloid in the brain and plasma was influenced by overall vascular risk score, and was only consistently observed in APOE ɛ4 carriers.
Benefits of Boxing and Exercise for Patients With Parkinson Disease
Timothy A. Leichliter, MD, a neurologist at Allegheny Health Network, provided context on the institution’s boxing program for Parkinson disease, and the need for patients to remain active.
Elevated Risk of Parkinson Disease Found in Rheumatoid Arthritis
Participants with rheumatoid arthritis had a 1.74-fold higher risk of PD compared with those without, raising importance of an elevated risk.
Large-Scale Analysis Finds Associations Between Obstructive Sleep Apnea and Long COVID
Positive associations between preexisting obstructive sleep apnea and probable post-acute sequelae among adults were attenuated but remained significant after adjusting for other comorbidities.
FDA Panel Votes in Favor of Gene Therapy SRP-9001 for Duchenne Muscular Dystrophy In Tight Decision
The FDA is set to make a final decision later this month and, if approved, SRP-9001 would be the first gene therapy specific to treat Duchenne muscular dystrophy.
New Study Identifies Immune Dysregulation and Neurocirculatory Abnormalities in Long COVID
Taken together, the findings added to the growing evidence that widespread immunological and autonomic nervous system changes may contribute to long COVID.
FDA Approves Brexpiprazole as First Therapy for Alzheimer Agitation
The approval was based on 2, positive phase 3 studies in which brexpiprazole-treated patients demonstrated a 31% greater reduction in frequency of agitation symptoms vs those on placebo.
Activated Microglia Contribute to Neurofilament Light Levels in Multiple Sclerosis
The strongest associations observed in the study were between microglial activation at the rim of chronic T1 hyperintense lesion and in the perilesional normal appearing white matter and serum neurofilament light.
FDA Approves Enzyme Replacement Therapy Pegunigalsidase Alfa for Fabry Disease
To date, the enzyme replacement therapy had been studied in a comprehensive clinical development program that comprised more than 140 patients with Fabry disease with up to 7.5 years of follow up treatment.
NeuroVoices: Sean Pittock, MD, on How Ravulizumab’s Effectiveness Speaks to Progress in NMOSD
The director of the Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology provided perspective on a phase 3 study of patients with NMOSD in which no relapses were recorded while on ravulizumab.
FDA Clears IND for Phase 1 Study of Monoclonal Antibody PMN310 for Alzheimer Disease
In transgenic mouse models, treatment with PMN310 resulted in preserved memory, to the extent that treated mice were indistinguishable from non-transgenic control mice.
AOC 1001 as a Potential Treatment for Myotonic Dystrophy Type 1
Nicholas Johnson, MD, MSci, FAAN, division chief of neuromuscular disorders and vice chair of research, Virginia Commonwealth University, provided insight on promising phase 1/2 data of AOC 1001 in myotonic dystrophy type 1.
Visual Performance, Not Retinal Thickness, Better Indicator of Dementia Risk in Parkinson Disease
Poor higher order vision at baseline was associated with worsening cognition and increased probability of death, dementia, or frailty over 3 years.
A New World: Digitally Assessing Cognitive Decline and Innovating the Clock Drawing Test
Digital technologies like the DCTclock are revolutionizing the way clinicians across all specialties can quickly assess for cognitive decline, an issue in today's aging society.
Intrathecal Mesenchymal Stem Cell-Neural Progenitor Therapy Shows Therapeutic Response in Subgroups of Progressive MS
In a subgroup of individuals with secondary progressive MS, 50% of patients on mesenchymal stem cell-neural progenitor therapy improved muscle strength compared with 33% of those on placebo.
Cardiovascular Factors Significantly Increases Dementia Risk in Epilepsy
In addition to increased risk of dementia, focal epilepsy was associated with widespread structural brain change reflected by lower total hippocampal and total gray matter volume.
Teriflunomide Shows Promise as Potential Treatment for Radiologically Isolated Syndrome
Teriflunomide, an FDA-approved therapy for relapsing forms of multiple sclerosis, resulted in an 62% risk reduction relative to placebo in preventing a first clinical event in patients with RIS.
FDA Clears Dry-Sensor, At-Home EEG Headset
Designed for self-directed use in a patient’s home or a healthcare facility, the Cumulus EEG device has potential to change the clinical trial landscape, allowing researchers to conduct more remote studies.
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