Experts discuss the transformative impact of B-cell–directed and high-efficacy disease-modifying therapies (DMTs) in managing Multiple Sclerosis, emphasizing early initiation to prevent disability while balancing safety, patient preferences, and long-term treatment considerations to optimize outcomes.
Experts discuss long-term management strategies for stable multiple sclerosis (MS), including continuing current therapy, careful treatment discontinuation, de-escalation, and switching therapies, all tailored to individual patient needs to balance disease control with minimizing risks and treatment burden.
Experts discuss the infection risks associated with long-term anti-CD20 therapies in multiple sclerosis (MS), emphasizing the need for careful monitoring, patient-specific risk assessment, and tailored de-escalation strategies to balance effective disease control with minimizing treatment-related adverse effects.
Experts discuss the rationale and patient-specific considerations for de-escalating therapy in multiple sclerosis (MS), particularly for those on anti-CD20 treatments, emphasizing the balance between maintaining disease stability and minimizing long-term risks such as infections and treatment burden through tailored adjustments based on clinical, radiological, and individual factors.
Experts discuss extended interval dosing (EID) of anti-CD20 therapies in multiple sclerosis (MS) as a promising strategy to maintain disease control while potentially reducing immunosuppression-related risks, highlighting early positive clinical experiences and the importance of careful patient selection and ongoing monitoring.
Experts discuss how de-escalation in multiple sclerosis (MS) balances maintaining disease control with reducing treatment burden by transitioning from fumarates to options such as cladribine or emerging Bruton tyrosine kinase (BTK) inhibitors, aiming for safer, more personalized long-term care.
Experts discuss the ongoing phase 4 COAST trial evaluating ozanimod as a step-down therapy for patients with stable multiple sclerosis (MS) on anti-CD20 treatments, highlighting careful patient selection, timing of initiation to balance disease control with immunosuppression risks, and the need for individualized decisions pending trial results.
Experts emphasize that long-term monitoring after stepping down from high-efficacy multiple sclerosis (MS) therapies requires individualized clinical, MRI, and laboratory assessments to promptly detect disease activity or complications, alongside clear patient communication about goals and risks; looking forward, novel treatments and improved biomarkers promise to enhance personalized, safer management strategies.
