American Epilepsy Society Annual Meeting

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Articles

The director of the Dartmouth Epilepsy Program and chairwoman of AES 2020 discussed some of the major topics from the previously completed annual meeting and where epilepsy research is trending.

2020 American Epilepsy Society Post-Conference Perspectives

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Despite significant improvements in Dravet syndrome, non-statistically significant reductions were observed in children with Lennox-Gastaut Syndrome. 

Soticlestat Reduces Seizure Frequency in Children With Dravet Syndrome

Chair and professor of neurology; Louis and Ruth Frank Professor of Neurosciences; section chief, Department of Neurology; and director, Dartmouth-Hitchcock Epilepsy Center, Geisel School of Medicine at Dartmouth

Videos

The director of the Dartmouth Epilepsy Program provided an overview of some of the critical unmet needs within ongoing epilepsy research following the recent AES Annual Meeting. 

Areas of Need in Epilepsy Research: Barbara Jobst, MD

Data suggest that treatment-emergent adverse events with adjunctive brivaracetam increased in incidence by number of lifetime AEDs. 

Fewer Lifetime AED Use Decreases Odds of Discontinuing Brivaracetam for Focal Seizures

The neurologist from Cleveland Clinic discussed perampanel’s unique mechanism of action. 

High Compliance and Good Tolerance in Perampanel Monotherapy for Partial-Onset Seizures

The director of the Dartmouth Epilepsy Program discussed a few of the notable highlights and themes from the recently completed American Epilepsy Society Annual Meeting.

Overarching Highlights from AES 2020: Barbara Jobst, MD

The observed increase in QOLIE-31 scores for patients with refractory disease was driven by increases on the energy-fatigue domain. 

Cenobamate Responders Achieve High Quality of Life in Epilepsy Scores

Valproic acid’s efficacy as a monotherapy is complicated by its previously demonstrated unsuitability for pregnant women. 

Combination Therapies Most Effective for Idiopathic Generalized Epilepsies

Specific health-related quality of life measures in physical activities, well-being, cognition, and social activities were improved among those who underwent the laser ablation procedure.

Stereotactic Laser Ablation Demonstrates Safety in Pediatric Epilepsy

The neurologist from the Comprehensive Epilepsy Care Center for Children and Adults, in St. Louis, Missouri, also discussed future studies planned for cenobamate. 