In this roundtable discussion, experts Scott Perry, MD, and Gita Gupta, MS, MS, reflected on key themes from 2025 Lennox-Gastaut syndrome (LGS) Research Meeting of the Minds. The conversation addressed pressing gaps in current LGS care, including the need for more effective, individualized treatment strategies and improved access to multidisciplinary resources. Panelists highlighted actionable approaches such as enhancing care coordination, expanding caregiver education, and fostering collaboration among stakeholders. The panel also considered how takeaways from the meeting could influence the design and focus of future clinical trials to better address the diverse needs of patients living with LGS.