Do lipid-lowering medications or low vitamin D levels in mid-life cause neurocognitive deficits? What effect does hypotension have on TBI outcomes?
Presentations at the American Heart Association Scientific Sessions examined the association of PCSK9 inhibitors and neurocognitive deficits, the effect of depth and dose of hypotension on mortality in traumatic brain injury, and a possible link between low vitamin D levels in mid-life and cognitive deficits 20 years later.
AHA 2016: Cardiovascular Health and Cognition
Neurological Effects of Proprotein Convertase Subtilisin/kexin Type 9(PCSK9) Inhibitors: Direct and Indirect Comparisons
Do proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors cause increased neurocognitive deficits?
PCSK9 inhibitors did not protect against stroke or TIAs, but despite previous studies, did not increase neurocognitive deficits.
Evaluation of Prehospital Hypotension Depth-duration Dose and Mortality in Major Traumatic Brain Injury
What effect does depth and duration of hypotension have on traumatic brain injury outcome (TBI)?
Usually in TBI, blood pressure is noted as hypotensive or not, but it’s influence on outcome may be much more important than previously thought.
Mid-Life Vitamin D Levels Are Not Associated with 20-Year Cognitive Decline in Whites and Blacks: the Atherosclerosis Risk in Communities (ARIC) Study
What is the long-term association of mid-life 25-hydroxyvitamin D (25(OH)D) levels on cognition?
Regardless of race, lower 25(OH)D in mid-life was not associated with cognitive decline over 20 years.
