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Opinion|Podcasts|August 4, 2025

B Cells as a Treatment Target in Myasthenia Gravis

Ali Habib, MD, and Arjun Seth, MD, discuss how B-cell–targeted therapies represent a promising upstream treatment approach for myasthenia gravis that could provide more sustained efficacy compared with current downstream treatments like complement inhibitors and FcRn antagonists, with CD19-targeting agents like inebilizumab showing particular promise in clinical trials for both acetylcholine receptor and MuSK antibody subtypes.

Time Codes

2:09 Pathophysiology of MG

6:32 Up/Downstream MG Targets

10:26 Recent Approvals in MG

14:20 B-Cell Targets in MG

17:07 Inebilizumab in MG

19:55 Anti-CD19 Targets in MG

23:11 Safety of MG Therapies

25:26 Role of Targeted Tx in MG

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