Best of MS: AAN 2017

Longitudinal Characterization of Cortical Lesion Evolution in Multiple Sclerosis by Ultra High Field MRI

What is the longitudinal evolution of cortical lesions in MS?

All cortical lesions detected at baseline remained at follow-up

Compared to previous reports at lower field strength, the rate of cortical lesion accumulation was significantly increased, particularly in SPMS.

Durable Reduction in MRI Disease Activity with Alemtuzumab in the Absence ofContinuous Treatment in Patients with Active Relapsing-Remitting Multiple Sclerosis Who Were Treatment-Naive: 6-Year Follow-up of the CARE-MS I Study

What were the 6-year outcomes in active RRMS patients who were alemtuzumab treatment-naïve at baseline?

Over 6 years, and in most cases in the absence of continuous treatment, alemtuzumab showed durable efficacy.

Environmental Risk Factors Associated with Pediatric MS: the Role of Remote Viral Infections and Vitamin D Revisited

Is there an association between viral infections, vitamin D deficiency, and pediatric-onset MS?

Preliminary results suggest an association between prior EBV and HSV-1 infection, and vitamin D deficiency and pediatric-onset MS.

Self-Reported Fatigue and Lower Limb Problems Predictive of Conversion to Secondary Progressive Multiple Sclerosis in an Aging Sample of Patients

Can patient-reported outcomes predict conversion to SPMS in an older population?

Fatigue and lower limb problems at baseline were strongly correlated (P=0.001) to conversion to SPMS in 5 years.