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Cognitive Decline in Amyloid-Negative Adults

Can amyloid accumulation predict a decline in episodic memory over time?


An analysis of 126 amyloid-negative adults aged 30 to 89 years with PET and a cognitive battery at baseline and at 4-year follow-up showed a relationship between specific regional accumulation of amyloid in posterior cortical regions and declining episodic memory.

The authors pointed out that assessing regional changes in amyloid accumulation may indeed be a marker for detecting subclinical amyloid related decline. As always, more research is needed.


1. Farrell ME, Chen X, Rundle MM, et al. Regional amyloid accumulation and cognitive decline in initially amyloid-negative adults. Neurology. 2018;91(19).