Computed Tomography Perfusion [CTP] In Stroke Management


Kevin Sheth, MD, discusses the role of computed tomography perfusion amid stroke diagnosis.

This is a video synopsis/summary of a Post Conference Perspectives involving Kevin Sheth, MD.

This is a video discussing the role of CT perfusion in the management of ischemic stroke patients, specifically focusing on an abstract presented regarding mechanical thrombectomy in ischemic stroke patients without salvageable brain tissue based on CT perfusion imaging.

Sheth explains that at Yale, CT perfusion is part of the routine clinical evaluation of acute stroke patients. It provides quantitative assessment of the infarct core and penumbral tissue to verify stroke diagnosis, characterize stroke severity, assist in family discussions, and guide potential interventions.

The methods of the discussed observational study involved evaluating multimodal CT scans, including CT perfusion, in ischemic stroke patients to develop mismatch profiles quantifying infarct core and penumbral tissue. These were related to details of endovascular treatment and functional independence at 90 days. Statistical adjustments were made for baseline differences.

Key findings were an interaction between recanalization status, age, and infarct extent, suggesting mechanical thrombectomy may be most effective in patients under 70 years old with moderate infarct volumes. Propensity score matching analyses in subgroups showed similar functional independence rates between patients.

Video synopsis is AI-generated and reviewed by Neurology Live editorial staff.

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