Drug Therapy in Epilepsy

Drug therapy is the mainstay of seizure treatment. A combination of two anti-epileptic drugs, ezogabine and retigabine, has proven to be an effective adjunctive therapy in adults in partial-onset seizure. Another drug, Fycompa, has received an expanded indication as an adjunctive treatment of primary generalized tonic-clonic seizures in patients 12 years of age and older with epilepsy. However, the anti-epileptic eslicarbazepine leads to a high frequency of hyponatremia and its use needs to be monitored, especially in elderly post-stroke patients.