Highlights: imaging the temporal dynamics & cellular architecture of seizures in Dravet syndrome, & reducing risk of spontaneous fetal loss.
Studies chosen as the best of epilepsy at AAN 2017 included an examination of the structure of seizures in a mouse model of Dravet syndrome, a look at seizure triggers, the impact of unplanned pregnancy on spontaneous fetal loss, and a review studying the feasibility of extrapolating adjunctive AED efficacy data from adults to a pediatric population.
In vivo Two-Photon Calcium Imaging of Excitatory Pyramidal Neurons and Inhibitory Fast-Spiking Parvalbumin-Positive Interneurons during Temperature-Induced Seizures in a Mouse Model of Dravet Syndrome
In a mouse model of Dravet syndrome, can researchers determine the temporal dynamics and cellular architecture of seizures?
For the first time, the structure of seizures was characterized through in vivo two-photon calcium imaging.
The EpiWatch app was successful in gathering research from a national cohort of patients with epilepsy; stress was the most common seizure trigger.
The Importance of Family Planning as a Determinant of Spontaneous Fetal Loss in Women with Epilepsy: Findings of the Epilepsy Birth Control Registry
The researchers advise prospective investigation, as these findings suggest unplanned pregnancies may double SFL risk.
Extrapolation of Efficacy Data from Adults with Primary Generalized Tonic-Clonic Seizures (PGTC) to Pediatric Patients: a Meta-Analysis of Published Clinical Trials
Due to the challenges of conducting clinical trials in children, can AED efficacy data in adults be used to extrapolate efficacy in pediatric patients with primary generalized tonic-clonic (PGTC) seizures?