Episode 114: AMX0035, Phase 3 PHOENIX Study, and Amylyx's Future Drug Development

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Mind Moments®, a podcast from NeurologyLive®, brings you an interview with Justin Klee and Josh Cohen. [LISTEN TIME: 19 minutes]

Justin Klee

Justin Klee

Episode 114 of the NeurologyLive® Mind Moments® podcast is now live! Scroll down to listen or click here to subscribe on your favorite streaming service.

The Mind Moments podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis, Parkinson disease, dementia, sleep disorders, and more.

Josh Cohen

Josh Cohen

Episode 114, "AMX0035, Phase 3 PHOENIX Study, and Amylyx's Future Drug Development" features a conversation with Justin Klee and Josh Cohen, cofounders and cochief executive officers of Amylyx Pharmaceuticals, who sat down at the recently concluded AAN Annual Meeting to discuss the results from the pivotal phase 3 PHOENIX trial (NCT05021536) of AMX0035 (Relyvrio) in patients with amyotrophic lateral sclerosis (ALS). The duo provided clarity on the findings, positive takeaways from the disappointing data, and the lessons learned in ALS drug development. In addition, the two provided commentary on the future plans of the therapy in other tauopathies like progressive supranuclear palsy and neurologic conditions like Wolfram syndrome. Furthermore, Klee and Cohen shared thoughts on the company's drug pipeline, including AMX0114, an antisense oligonucleotide in development for patients with ALS.

The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

This episode is brought to you by Medical World News, a streaming channel from MJH Life Sciences®. Check out new content and shows every day, only at medicalworldnews.com

EPISODE BREAKDOWN

  • 1:05 – Decision behind removing AMX0035 from market
  • 3:00 – Lessons from PHOENIX, AMX0035 drug development program
  • 6:45 – Unraveling PHOENIX study data 
  • 10:00 – Neurology News Minute
  • 12:10 – Potential of AMX0035 in other tauopathies, neurologic conditions
  • 15:00 – Outlook of antisense oligonucleotide AMX0114 in ALS

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