Key Takeaways for Treating OFF Episodes in PD

EP: 1.Role of Levodopa in Managing Parkinson Disease

EP: 2.ON Time vs OFF Episodes in PD

EP: 3.Identifying OFF Episodes in PD

EP: 4.OFF Episodes During Progression of PD

EP: 5.Impact of OFF Episodes on QOL in PD

EP: 6.Raising Awareness of OFF Episodes in PD

EP: 7.Challenges With OFF Episodes in PD

EP: 8.Initiating Patient Conversations for ON/OFF Episodes in PD

EP: 9.Managing OFF Episodes in PD

EP: 10.Multidisciplinary Management of OFF Episodes in PD

EP: 11.Treatment Selection for Managing OFF Episodes in Parkinson Disease

EP: 12.Initiating Treatment for OFF Episodes in Parkinson Disease

EP: 13.Unmet Needs in Managing OFF Episodes in Parkinson Disease

EP: 14.Using On-demand Therapies for the Management of OFF Episodes in PD

EP: 15.Assessing Effectiveness of OFF Episode Treatment in PD

EP: 16.Novel Therapeutic Administration Routes for Managing PD OFF Episodes

EP: 17.Apomorphine Infusion Devices to Manage OFF Episodes in PD

EP: 18.Emerging Therapies for the Management of PD OFF Episodes

Now Viewing

EP: 19.Key Takeaways for Treating OFF Episodes in PD

Stuart Isaacson, MD: That was a fascinating discussion with everyone. Take home messages perhaps. Laxman, do you have a take home message for a neurologist treating OFF episodes?

Robert A. Hauser, MD, MBA: Probably 2. One, query your patients about OFFs. If they don't know what you mean, educate your patients and their caregivers about what OFFs occurs. Because when they emerge, you want to have some vocabulary that's in common. Probably the second is we have numerous therapies coming out, we have numerous therapies that have come out. And if your patients are experiencing OFFs, it's worth trying these on-demand class of therapies, future class when they come out with the long acting levodopas or the subcutaneous infusions. Parkinson's has changed so much even in the last 5, 6 years. I suspect in the next 5, 7 years it will be even differently treated than how we treat it now.

Stuart Isaacson, MD: Raj, last take home message.

Rajesh Pahwa, MD: One, educating both the patient and the neurologist about what OFF is and how to discuss OFF. And the second thing is every patient is different, every patient's OFF is different, the severity of OFF is different. You asked earlier a question, is our goal to eliminate OFF completely? Yes, that is the goal. Whether we can reach that or not is a different thing, but what can we do to completely eliminate OFF in our patients, not at the risk of having more dyskinesias but giving them more good on time during the day.

Stuart Isaacson, MD: Bob?

Robert A. Hauser, MD, MBA: Yes as a field, we continue to make good progress in longer duration therapies and continuous delivery of efficacious medications, so that continues onward. And I'm also struck by the fact that the answers to a lot of your questions were talk to the patients and understand how they're doing through the day so you can make appropriate adjustments.

Stuart Isaacson, MD: Thanks to all of you for this very informative discussion. And thank you for watching this neurology live peer exchange. If you enjoyed the content, please subscribe for our e-news letters to receive upcoming peer exchanges and other great content right in your inbox. Thank you.

Transcript Edited for Clarity