Quiz|Articles|September 20, 2026 (Updated: September 17, 2026)

NeurologyLive® Brain Games: September 20, 2026

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Key Takeaways

  • A Sunday-release cadence structures a three-question format intended to assess breadth across major neurology subspecialties.
  • Clinician- and expert-written questions integrate both clinical practice and historical context within neurological disease domains.
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Test your neurology knowledge with NeurologyLive®'s weekly quiz series, featuring questions on a variety of clinical and historical neurology topics. This week's topic is Parkinson disease biomarkers!

Welcome to NeurologyLive® Brain Games! This weekly quiz series, which goes live every Sunday morning, will feature questions on a variety of clinical and historical neurology topics, written by physicians, clinicians, and experts in the fields of neurological care and advocacy.

Test your mettle each week with 3 questions that cover a variety of aspects in the field of neurology, with a focus on dementia and Alzheimer disease, epilepsy and seizure disorders, headache and migraine, movement disorders, multiple sclerosis, neuromuscular disorders, sleep disorders, and stroke and cerebrovascular disease.

This week's questions includes the theme of Parkinson disease biomarkers!

Click here to check out the prior iterations of Brain Games.

Interested in submitting quiz questions? Contact our editor, Marco Meglio, via email: [email protected].

A 67-year-old patient has bradykinesia, rigidity, and a resting tremor, but the clinical diagnosis remains uncertain. Cerebrospinal fluid testing demonstrates a positive α-synuclein seed amplification assay (αSyn-SAA). Which interpretation is most appropriate?


A neurologist is evaluating a patient with suspected Parkinson disease and is considering dopamine transporter (DAT) SPECT imaging. Which finding would most strongly support a presynaptic dopaminergic deficit?


A patient with early Parkinson disease has a positive CSF αSyn-SAA. Investigators subsequently observe that the assay remains positive over serial assessments despite clinical progression. Which statement best describes the current limitation of αSyn-SAA as a longitudinal biomarker?


How did you do on this week's quiz? Let us know with a response to the poll below. Don't forget to share and compare your results with your friends!

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