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“Patients with low baseline plasma phospho-tau exhibited a more pronounced response to CT1812, suggesting a targeted approach may enhance therapeutic outcomes in Alzheimer disease.”
CT1812 (Cognition Therapeutics) is an oral investigational, small-molecule sigma-2 receptor modulator in development for the treatment of Alzheimer disease (AD) and dementia with Lewy bodies. The therapy aims to displace Aβ oligomers from receptors on neuronal synapses, and thereby potentially protecting synapses from their toxic effects. The phase 2 SHINE trial (NCT03507790) assessed safety, tolerability, and effects of CT1812 on cognitive function in patients with mild-to-moderate AD.
A new prespecified analysis of data from SHINE showed that those treated with CT1812 who had baseline plasma p-tau217 below the median experienced a 95% slowing of cognitive decline, as measured by the 11-item Alzheimer’s Disease Assessment Scale–Cognitive subscale. The company noted that these same participants showed a 108% slowing, when measured by Mini-Mental State Examination. Notably, patients in the placebo groups for both analyses reported cognitive decline. Researchers also noted that complete results from this trial are anticipated to offer evidence as to whether the therapy can modify the disease course in this patient population.
These results were presented at the
