Relapsing-Remitting MS: Current Treatment Gaps

EP: 1.Diagnosing MS: Referring to the Revised McDonald Criteria

EP: 2.Diagnosing MS: Criteria Used to Assess Lesions

EP: 3.Differentiating Between the Subtypes of MS

EP: 4.Early, Aggressive Therapy for Relapsing-Remitting MS

EP: 5.Treating RRMS: Low Vs High-Efficacy Therapy

EP: 6.Counseling Patients On High-Efficacy Therapy for RRMS

EP: 7.High-Efficacy Therapies Used to Treat RRMS

EP: 8.Impressions of a 35-Year-Old Man With Relapsing MS

EP: 9.High-Efficacy Therapy for a 35-Year-Old Man With Relapsing MS

EP: 10.Ofatumumab for Relapsing MS

EP: 11.Treating RRMS With Anti-CD20 Therapy During COVID-19

EP: 12.Impressions of a 25-Year-Old Woman With Relapsing MS

EP: 13.Counseling a 25-Year-Old Woman With Relapsing MS

EP: 14.Monitoring Treatment Response in Relapsing-Remitting MS

EP: 15.Treating Relapsing-Remitting MS: Switching Therapy

EP: 16.Best Strategies for Controlling Relapsing-Remitting MS

EP: 17.Exciting Developments in Relapsing-Remitting MS

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EP: 18.Relapsing-Remitting MS: Current Treatment Gaps

EP: 19.Managing Multiple Sclerosis in the Community Setting

Scott D. Newsome, DO, MSCS, FAAN: Pat, why don’t you tell us about the future for treating patients? Talk about the symptomatic care and the healthy lifestyle choices because we always talk about the disease-modifying therapies [DMTs] and what the MRI scan shows, how much reduction in relapses in this study. Until recently, there has not been a lot of focus on wellness, and there are definitely studies out there that are showing the impact of healthy lifestyle and wellness.

Patricia K. Coyle, MD: I will start by saying that we need to decrease our misdiagnosis rate as we try to make the diagnosis as early as possible. To me, that argues for a thorough work-up. Secondly, we need to get treatments for neurodegeneration, and we need CNS [central nervous system] repair. Those are gaps; those are lax. We need to develop them. Thirdly, you are speaking about things that boost CNS resiliency and the ability to repair, and this makes wellness important. It makes healthy lifestyle choices important, such as not smoking and maintaining an optimum body weight. Stimulation mentally, socially, and physically becomes important. It is interesting, we come back to this aging phenomenon. We know that, as the brain ages, it becomes less able to contract, and we are beginning to see people talk about the development of treatments that might rejuvenate the brain. That is an exciting possibility in MS [multiple sclerosis].

If you look at the person in totality, quality of life matters. Quality of life can have a negative impact, and the key to quality of life is optimum management of symptoms. We do not talk about it that much, but we recognize symptoms in MS. Some of them can clearly be injurious to the central nervous system, such as depression, which is a comorbid condition as well. Developing better symptomatic strategies is a key important component. I will also add that we have heard about developments in better following patients, parameters to follow. Looking at activity outside of the brief time in the outpatient department and tracking activities at home is going to be a promising frontier for us in the future.

Scott D. Newsome, DO, MSCS, FAAN: I agree. There are studies looking at actigraphy, which watches how much activity someone does. There might be something here. People are studying this, and that may help us care for people in a greater way such that, when the patient comes in and says, “I am exercising. I am getting my 10,000 steps,” I have the data that show they are or are not. They may be sitting on their couch like I will be this weekend.

We have to treat the person as a whole. As was mentioned previously, it is not just about the DMTs. The DMTs are not necessarily going to improve the quality of life that the person has today. We have to focus on treating the whole person, and that involves symptomatic interventions in care, exercise, and all the things that go into it.

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Transcript Edited for Clarity