
Therapeutic Potential of Combination Strategies to Treat Alzheimer Disease: Lloyd Tran, PhD
The chairman and chief executive officer at Biomed discussed the additive benefits of combination therapy for Alzheimer disease, providing context on the strengths of different drugs and how it might lead to a more precision medicine approach. [WATCH TIME: 6 minutes]
WATCH TIME: 6 minutes
"Combination therapy gives us the best of both worlds, offering a holistic approach where one treatment complements and balances the other."
For years, the idea of combining medications to treat neurodegenerative disorders seemed farfetched, simply for the fact that there had been little success with drug development, with only symptomatic treatments available. Since 2022, the Alzheimer disease (AD) community has witnessed 2 new approved treatments—lecanemab (Leqembi; Eisai) and donanemab (Kisulna; Eli Lilly)—that target and remove amyloid-ß from the brain, otherwise considered a hallmark of AD pathology.
At the
The study, expected to be conducted across 30 sites in the US and worldwide, serves as a testament to the progress in the field, and the potential for combination approaches in AD. During the conference, NeurologyLive® sat down with Lloyd Tran, PhD, chairman and chief executive officer at Biomed, to discuss the unique benefits of integrated therapy methods. He spoke on the additive benefits this approach may bring, the customization and personalization to treatment plans, and the advantages in targeting various brain areas simultaneously. Furthermore, he also stressed how studies like this allow for greater collaborative opportunities, bringing together smaller companies and larger firms to enhance market strength and patient care outcomes.
REFERENCE
1. Tran L, Tran ZV, Vu F, et al. Phase 3 clinical protocol: placebo-controlled, double-blind, parallel-group to study safety and efficacy of NA-831 in combination with lecanemab in subjects with early Alzheimer’s disease. Presented at: AAIC; July 28-August 1, 2024; Abstract 95755
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