Alzheimer’s Association International Conference 2018

The Alzheimer’s Association International Conference on Alzheimer’s Disease (ICAD) held in Chicago, Illinois, from July 22 to July 26, 2018. The meeting convened the world’s leading researchers, investigators, and clinicians to share research discoveries that will lead to methods of prevention, treatments, and diagnosis.
After identifying and reviewing 76 randomized trials, combination therapy with memantine and AChEIs is confirmed to have no additional benefits over monotherapy.
Lutz Frölich, MD, PhD, spoke about the importance of continuing with research in light of negative trials in Alzheimer disease.
Hendrix spoke to the challenges he and colleagues come across, as well as his hope for the promising future.
Selkoe spoke to a number of topics in the Alzheimer space, including the challenges in the field and his excitement for the future.
Lutz Frölich, MD, PhD, discussed the imperativeness of collaboration between stakeholders—clinicians, pharmaceutical companies, researchers—in developing therapies for Alzheimer disease.
The neurosurgeon from Sunnybrook Health Sciences Centre spoke about his excitement about where the medical community is at, at this point, in the understanding of Alzheimer disease.
Livingston spoke to a number of topics in the dementia space, including the challenges clinicians face and her hope for the future.
The head of the Department for Geriatric Psychiatry, Central Institute of Mental Health talked about the biggest challenges facing medicine in treating and understanding Alzheimer disease.
DREAMS-START demonstrates that a manual-based psychological treatment for sleep disorders in dementia is feasible and acceptable.
Nabilone significantly improved agitation, neuropsychiatric symptoms, cognition and nutrition in patients with moderate-to-severe Alzheimer disease.
The founder and CEO of T3D Therapeutics, Inc., spoke about T3D’s desire to go against the grain and trend in the therapeutic development for mild to moderate Alzheimer disease.
The head of the Department for Geriatric Psychiatry, Central Institute of Mental Health discussed his thoughts about patients with mild dementia and prodromal Alzheimer disease.
Data back a 4-fold higher dose of crenezumab in the CREAD 1 and CREAD 2 trials than used in phase II.
Hampel looks to the future of the Alzheimer space and sees promise, especially since there’s transfertilization from other advanced science fields in medicine like oncology, diabetes research and rheumatology.
 
The vice president and head of Alzheimer’s Disease, Dementia, and Movement Disorders in Late Stage Clinical Development at Biogen spoke about the upcoming TANGO II trial in Alzheimer disease.
Davangere P. Devanand, MBBS, MD, discussed the possibility of neurologists prescribing low-dose lithium for patients with Alzheimer and symptoms of agitation.
The Director of the University of Rochester Alzheimer's Disease Care, Research and Education Program discussed the ongoing study, which is exploring s-citalopram in patients with Alzheimer who also have symptoms of agitation.
Study results suggest that agonist stimulation of PPAR delta may be an effective therapeutic strategy to addressing dysfunctional metabolism in Alzheimer disease.
Haeberlein spoke about a number of topics in the Alzheimer space, including the progress that has been made and her excitement for the future.
The phase IIb/III study is scheduled to initiate enrollment of approximately 450 patients, randomized 1:1:1 to 2 different ANAVEX 2-73 doses or placebo.
The professor of psychiatry in neurology at the Gertrude H. Sergievsky Center at Columbia University Medical Center spoke about the possibility of using lithium for agitation in Alzheimer.
Higher doses of gantenerumab, a monoclonal antibody designed to bind to aggregated Aβ and remove beta plaques, will be investigated in phase III trials.
The senior lecturer in Clinical Pharmacy at Aston University talked about issues facing the medical community in treating those with dementia who have sleep problems.
The results conclude that treatment with crenezumab was associated with a consistent decrease in Aβ oligomer levels in the CSF.
This technology offers a non-invasive, image-guided and reversible approach to blood-brain barrier, suggesting the possibility of its use in Alzheimer disease.
The senior lecturer in Clinical Pharmacy at Aston University spoke about the findings of the ZED study, which looked into the use of hypnotic z-drugs.
ANAVEX 2-73 is being studied as the first potential precision medicine biomarker-guided, targeted therapeutic in Alzheimer disease.
 
The director of the University of Rochester Alzheimer's Disease Care, Research and Education Program spoke about the need to rethink trial design and Alzheimer neuropsychiatric symptom management.
This is the first large late-stage clinical trial to further support the amyloid hypothesis.
The SPRINT MIND trial found a statistically significant lower rate of new cases of mild cognitive impairment in the intensive treatment group.
The psychiatry and pharmacology professor spoke about the results from the first clinical trial that showed that a cannabinoid can decrease agitation in Alzheimer disease. 
Efficacy was demonstrated in this patient population at the primary endpoint of 6 weeks, especially in those with more severe baseline NPI-NH-PS.
Data from an interim analysis of the lumateperone large phase III clinical trial for agitation in subjects with dementia is expected by the end of 2018. 
These guidelines will provide primary clinicians and the specialist community an important new tool to more accurately diagnose patients.

About the Alzheimer’s Association International Conference 2018:

The Alzheimer’s Association International Conference 2018 is the world’s largest forum for the dementia research community, and welcomed the world’s top neurology experts. Those who attended the meeting gained valuable insight from some of the most respected leaders in the field. NeurologyLive offers the most up-to-date information regarding existing Alzheimer’s treatment options, as well as data from clinical trials evaluating new and emerging therapies, to those unable to travel to network with the Alzheimer’s Association in Chicago.
 
This Conference Coverage page at NeurologyLive is a full-service resource center for the latest from AAIC 2018, including key developments from research that may potentially lead to a better understanding of Alzheimer’s disease causes, methods of early diagnosis, symptom management, and prevention. It serves as a hub of information and news from the conference, and includes focal coverage right from the floor.
 
For related content, check out NeurologyLive’s Alzheimer’s Disease and dementia Condition Center page.