Opinion

Video

Contribution of Multiple Pathways to the Development of Alzheimer’s Disease

Sharon Cohen, MD, and Marwan Sabbagh, MD, discuss the current understanding of tau as a marker of neuronal injury and its role in the pathophysiology of Alzheimer's disease, particularly focusing on the significance of phosphorylated tau and neurofibrillary tangles in the disease process.

  • What is the current thinking on multiple mechanisms contributing to different aspects of pathology of Alzheimer’s disease?
    • What role does tau, its phosphorylated form, and neurofibrillary tangles of tau protein play in pathophysiology of Alzheimer’s disease?
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