Contribution of Multiple Pathways to the Development of Alzheimer’s Disease

Sharon Cohen, MD, and Marwan Sabbagh, MD, discuss the current understanding of tau as a marker of neuronal injury and its role in the pathophysiology of Alzheimer's disease, particularly focusing on the significance of phosphorylated tau and neurofibrillary tangles in the disease process.

EP: 1.Apolipoprotein E4 in Alzheimer’s Disease

EP: 2.Importance of Early Diagnosis of Alzheimer’s Disease

EP: 3.Amyloid Precursor Protein and Amyloid Beta Species in Alzheimer’s Disease

EP: 4.Amyloid Cascade Hypothesis of Alzheimer’s Disease

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EP: 5.Contribution of Multiple Pathways to the Development of Alzheimer’s Disease

EP: 6.Utilization of Neuroimaging in Alzheimer’s Disease

EP: 7.CSF Testing and Blood-based Biomarkers in Alzheimer’s Disease

EP: 8.Utilization of APOE4 Genotype in Management of Alzheimer’s Disease

EP: 9.Alzheimer’s Disease Pipeline

EP: 10.The Future Outlook for Alzheimer’s Disease

What is the current thinking on multiple mechanisms contributing to different aspects of pathology of Alzheimer’s disease?
- What role does tau, its phosphorylated form, and neurofibrillary tangles of tau protein play in pathophysiology of Alzheimer’s disease?

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