Opinion|Videos|May 13, 2024

Amyloid Precursor Protein and Amyloid Beta Species in Alzheimer’s Disease

The panel provides an overview of amyloid precursor protein (APP) and the generation of amyloid β (Aβ) peptides, Aβ42 and Aβ40, while also discussing which soluble or insoluble Aβ species (monomers, oligomers, protofibrils, or amyloid plaques) contribute to neuronal damage and the clinical manifestation of Alzheimer's disease.

What is amyloid precursor protein (APP)? How are amyloid β (Aβ) peptides, Aβ42 and Aβ40, generated?

Which soluble or insoluble species of Aβ (monomers, oligomers, protofibrils or amyloid plaques) contribute to neuronal damage and clinical manifestation of Alzheimer’s disease?

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