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Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending May 16, 2025. 

NeurologyLive® Friday 5 — May 16, 2025

The FDA approved Fujirebio's Lumipulse G p-tau217/β-Amyloid 1-42 Plasma Ratio as the first in vivo blood test for early Alzheimer’s detection, demonstrating high diagnostic accuracy with strong correlations to amyloid PET and CSF test results.

FDA Clears Lumipulse Plasma Ratio as First Blood Test for Diagnosing Alzheimer Disease

Markted as Brekiya, Amneal Pharmaceuticals’ newly approved therapy offers a self-administered version of dihydroergotamine mesylate for adults with migraine or cluster headache.

FDA Approves First Autoinjector Form of DHE for Acute Migraine and Cluster Headache

Targeting tau pathology in preclinical Alzheimer disease could benefit from recruiting individuals positive for both Aß and GFAP biomarkers, improving patient selection and cost effectiveness.

Plasma GFAP May Enrich Patient Selection, Reduce PET Scans Required for Alzheimer Trials

Videos

The executive vice president of research at the National MS Society talked about the significance of the Dystel Prize, honoring researchers in MS whose scientific work has led to meaningful diagnostic or therapeutic advancements. [WATCH TIME: 2 minutes]

Recognizing Scientific Excellence and Impact in Multiple Sclerosis Research: Bruce Bebo, PhD

, has been with the team since September 2022. Follow her on Twitter 

The research portfolio director at the Muscular Dystrophy Association discussed the evolving ALS therapeutic landscape, highlighting advances in genetic and RNA-based interventions. [WATCH TIME: 6 minutes]

Advancing ALS Through Gene Therapies, Early Intervention, and Multidisciplinary Care: Brian Lin, PhD

Marco Meglio, Assistant Managing Editor for 

, has been with the team since October 2019. Follow him on Twitter 

Seif Elbualy, MD, discusses his role at the Brain and Spine Symposium and shares insights on the future of interventional pain management, evolving techniques, and pharmaceutical innovation.

Overviewing 2025 Baptist Health Brain and Spine Symposium: Exploring New Options in Chronic Pain Management

The director of the Tuberous Sclerosis Program at Cleveland Clinic provided clinical commentary on a novel clustering analysis in TSC, revealing how phenotype-genotype insights can lead to more personalized treatment and surveillance.

NeuroVoices: Ajay Gupta, MD, on Phenotyping Tuberous Sclerosis Complex Into Disease Clusters

NeurologyLive is your direct connection to the latest neurology news and interviews with expert neurologists in multimedia formats.

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Advances in the Management of Excessive Daytime Sleepiness and Narcolepsy

In this program, sleep experts will discuss the importance of timely and accurate diagnosis, recent approvals and available treatment options for the management of narcolepsy and excessive daytime sleepiness.

Experts provide an overview of excessive daytime sleepiness and narcolepsy.

Narcolepsy  Overview 

Anne Marie Morse, DO, FAASM, discusses the burden and risk factors associated with excessive daytime sleepiness and narcolepsy.

Burden and Risk Factor of Narcolepsy

Experts discuss narcolepsy diagnosis and the challenges associated with it.

Diagnosis of Narcolepsy

Thomas E. Scammell, MD, discusses evaluating excessive daytime sleepiness (EDS).

EDS Evaluation 

Debra Stultz, MD, provides an overview of the available resources that are available for narcolepsy treatment.

Available Resources for Narcolepsy Treatment

Neurology experts describe the goals of therapy for narcolepsy treatment. 

Goals of Therapy for Narcolepsy 

Karl Doghramji, MD, FAASM, DFAPA, provides an overview of the pharmacological treatment options for narcolepsy.

Pharmacological Treatment Options for Narcolepsy

Neurology experts discuss excessive daytime sleepiness (EDS) and narcolepsy treatment options. 

EDS and Narcolepsy Treatment Options

Thomas E. Scammell, MD, provides an overview of the mechanism of action of pitolisant for the treatment of narcolepsy.

Pitolisant: Mechanism of Action

Anne Marie Morse, DO, FAASM, discusses the efficacy and safety profile of pitolisant for the treatment of narcolepsy.

Pitolisant Efficacy and Safety

Experts discuss the efficacy and safety profile of solriamfetol for the treatment of narcolepsy.

Solriamfetol Efficacy and Safety

Experts discuss sodium oxybate and antidepressants for treatment of cataplexy.

Sodium Oxybate and Antidepressants for Treatment of Cataplexy 

Neurology experts discuss the unmet needs in narcolepsy treatment and share clinical pearls from their experiences. 

Unmet Needs in Narcolepsy and Clinical Pearls

Peer Exchange

Clinical

 Peer Exchange video series features panels of expert physicians engaging in in-depth discussions about practice-changing treatments, challenges in care, and the future paradigm of management for neurologic diseases.

Diagnosis of Narcolepsy

EP: 1.Narcolepsy Overview

EP: 2.Burden and Risk Factor of Narcolepsy

EP: 3.Diagnosis of Narcolepsy

EP: 4.EDS Evaluation

EP: 5.Available Resources for Narcolepsy Treatment

EP: 6.Goals of Therapy for Narcolepsy

EP: 7.Pharmacological Treatment Options for Narcolepsy

EP: 8.EDS and Narcolepsy Treatment Options

EP: 9.Pitolisant: Mechanism of Action

EP: 10.Pitolisant Efficacy and Safety

EP: 11.Solriamfetol Efficacy and Safety

EP: 12.Sodium Oxybate and Antidepressants for Treatment of Cataplexy

EP: 13.Unmet Needs in Narcolepsy and Clinical Pearls