Could marijuana use increase the risk of developing Alzheimer disease?
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In this Medical News Minute, developed exclusively for Neurology Times, Dr. Bobby Lazzara reports on a study investigating perfusion in specific brain regions of marijuana users, Alzheimer patients, and controls. The hippocampus, a key target of Alzheimer disease pathology, was especially useful in distinguishing marijuana users from healthy controls.
The phase 3 TRONTIER 1 and 2 trials will test whether trontinemab's faster brain entry and rapid amyloid clearance translate into slower clinical decline in early Alzheimer disease.
Joanna Wardlaw, MD, Professor of Applied Neuroimaging at the University of Edinburgh, discusses the evolving understanding of cerebral small vessel disease, emerging therapeutic approaches, and the makings behind a successful trial.
Fast track status covers AV-1959R, an investigational amyloid-beta vaccine, for preventing Alzheimer disease in cognitively unimpaired adults with amyloid pathology.