Implications of Ozanimod Discontinuation Data for MS Care

EP: 1.Brain and Cognitive Changes in Multiple Sclerosis

EP: 2.Association Between Brain Volume and Long-term Cognition in Relapsing Multiple Sclerosis

EP: 3.Cognitive Care Recommendations

EP: 4.Factors Necessitating Treatment Change in Multiple Sclerosis

EP: 5.Ozanimod in DMT Naïve vs Experienced Patients with Relapsing Multiple Sclerosis

EP: 6.Clinical Pearls for MS Management in Everyday Practice

EP: 7.Treatment Discontinuation in Multiple Sclerosis

EP: 8.Relapse Following Discontinuation of Ozanimod

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EP: 9.Implications of Ozanimod Discontinuation Data for MS Care

EP: 10.Managing Relapses in Patients With Multiple Sclerosis

EP: 11.Long-Term Outcomes With Ozanimod Based on Number of MS Relapses

EP: 12.Advice for Clinical Management of Multiple Sclerosis

Wallace Brownlee, MBChB, PhD, FRACP: Overall the study provides reassuring data that the risk of relapse in people discontinuing ozanimod is low. About 1 in 50 people experienced a relapse, or 2.3% of the overall population of patients discontinuing treatment. Overall, the relapse we’ve seen were of mild to moderate severity, which was reassuring, and they weren’t associated with any permanent or severe increase in disability. There were no cases of rebound, which is our big fear when discontinuing other S1P modulators. Of note, the relapse risk was higher in women who stopped treatment for family planning. This has direct implications for treatment decisions in this patient group.

When I’m approaching patients who want to discontinue their treatment, the first step is to discuss it with the patients and explore their reasons for wanting to stop therapy. In many patients, it will be appropriate to move on to another disease-modifying therapy. For example, if the patient is experiencing adverse effects or issues with tolerability with their current medication, then coming up with a new treatment plan should be fairly straightforward. Decisions are more difficult in women who are planning families, and this study highlights how difficult some of these clinical issues are.

One of the difficulties is that the process of conception isn’t always straightforward, and we don’t know how long it will take for women to become pregnant. Therefore, that can lead to a long period without any disease-modifying therapy. In general, I encourage women who are stopping treatments like ozanimod or other therapies that aren’t safe during conception and pregnancy to consider an alternative disease-modifying therapy that may facilitate family-planning decisions. In that regard, there are some very helpful guidelines available from professional bodies, such as the Association of British Neurologists.

Transcript edited for clarity