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Studies have found that children who take antiepileptic drugs (AEDs) have lower bone mineral density and increased fracture risk, compared with those who do not take AEDs.

 of children with epilepsy treated with AEDS matched to twins, siblings, or cousins not on AEDs found increased prevalence of bone fractures and decreased bone volume in AED users.

Some researchers have postulated that impaired vitamin D synthesis related to AEDs may explain the association, but vitamin D status was not statistically significant between cases and controls in this study.

Impaired bone and muscle development in young people treated with antiepileptic drugs

Epilepsy

 epilepsy clinical focus page provides information, podcasts, videos, and news about the latest FDA actions, clinical guideline updates, study and clinical trial findings, and interviews with physicians related to epilepsy and related epileptic conditions, including Lennox-Gastaut syndrome, Dravet syndrome, tuberous sclerosis complex, focal seizures, nonmotor seizures, and more.

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