NeurologyLive® Year in Review 2025: Top Podcast Episodes

Throughout the course of the year, the NeurologyLive^® team put together nearly 30 episodes of our podcast, Mind Moments^®, which features quick, digestible interviews with experts on trending topics in clinical neurologic care. The podcast, which releases new episodes every other Friday (in addition to special episodes, on occasion), is available to listen across most major podcast platforms.

Here, we'll highlight just some of the most-listened episodes on NeurologyLive this year. Click the buttons to check out more of these conversations, and be sure to subscribe to our show to never miss an episode! Click here to subscribe to the Mind Moments podcast. Be sure to leave a rating and review for the show.

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Click the listen now buttons for more details and information about each episode.

1. Episode 143: Bemdaneprocel and the Future of Cell Therapy in Parkinson Disease

In this episode, Rajesh Pahwa, MD, director of the Parkinson’s Disease and Movement Disorder Center at the University of Kansas Medical Center, discusses the phase 3 exPDite-2 trial evaluating bemdaneprocel, an investigational cell therapy for Parkinson disease (PD).

EPISODE BREAKDOWN

• 1:00 – Mechanism and rationale behind bemdaneprocel as a dopaminergic cell therapy
• 3:00– Key design considerations for conducting a registrational phase 3 cell therapy trial
• 5:25 – Trial structure, eligibility criteria, and ongoing patient recruitment
• 6:35 – Neurology News Minute
• 8:45 – Significance of reaching phase 3 with a cell therapy in Parkinson disease
• 10:20 – Future role of cell therapy within the Parkinson disease treatment landscape

2. Episode 154: NEALS 2025: Takeaways That Matter for ALS Care

In this episode, ALS experts Jinsy Andrews, MD, MSc, and James Berry, MD, MPH, reflected on key themes from the 2025 NEALS Annual Meeting, now reintroduced as the Network of Excellence for ALS. They discussed format changes that elevated lightning science, the expanding gene therapy pipeline, and a growing slate of NEALS-affiliated trials.

EPISODE BREAKDOWN

• 1:05 – Reflections on meeting highlights and NEALS rebranding into a global network
• 5:00 – Notable NEALS-affiliated trials and promising new mechanisms in ALS care
• 12:45 – Combination therapy strategies and future approaches in ALS research
• 15:20 – Neurology News Minute
• 18:00 – Expanding clinical trial access for rare and genetic ALS subtypes
• 22:10 – Building momentum and expectations for the 2026 NEALS Annual Meeting

3. Episode 139: Sleep and Seizures: Emerging Insights From AAN 2025

In this episode, Nancy Foldvary-Schaefer, DO, director of the Sleep Disorders Center at Cleveland Clinic, reflected on key sleep-related topics presented at the 2025 American Academy of Neurology (AAN) Annual Meeting, held April 5–9 in San Diego, California.

EPISODE BREAKDOWN

• 1:00 – Key sleep topics discussed at AAN 2025 and the growing interest in hypersomnia
• 5:45 – Development and purpose of the SLEEP mobile app by Cleveland Clinic
• 10:35 – Findings on obstructive sleep apnea prevalence in adults with epilepsy
• 15:05 – Neurology News Minute
• 17:10 – The need for sleep disorder screening in epilepsy clinical trials
• 19:45 – Exploratory findings on SSRI use and respiratory patterns in patients with epilepsy

4. Episode 147: Improving Quality of Life in Movement Disorders Through Nonmotor Symptom Management

In this episode, Alexa Dessy, MD, clinical assistant professor in movement disorders at Jefferson Health, shares a comprehensive look at modern-day care strategies for patients with Parkinson disease and other movement disorders.

EPISODE BREAKDOWN

• 1:00 – How movement disorder diagnosis is approached through history, physical exam, and phenomenology
• 4:05 – What makes certain movement disorder cases complex, and how diagnostics like genetics and imaging are used
• 6:20 – Neurology News Minute
• 8:45 – How nonmotor symptoms in Parkinson (fatigue, constipation, sleep) are managed with lifestyle strategies
• 12:30 – Approaching therapeutic communication and expectation-setting with patients and families

5. Episode 151: ECTRIMS 2025 Meeting Highlights and Clinical Takeaways

In this episode, Daniel Ontaneda, MD, PhD, neurologist at Cleveland Clinic’s Mellen Center for MS, shared his reflections from the 2025 European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress, held September 24-26, in Barcelona, Spain.

EPISODE BREAKDOWN

• 1:00 – Overall impressions of ECTRIMS 2025, highlighting diagnostic updates, precision medicine, and late-breaking trial results
• 4:10 – Expanding focus on individualized care, especially interval-adjusted dosing strategies for B-cell therapies
• 7:50 – Neurology News Minute
• 9:50 – Insights on emerging therapeutic approaches including BTK inhibitors, CAR-T therapies, and remyelination strategies
• 14:35 – Growing attention toward NMOSD, MOGAD, and other autoimmune conditions within neuroimmunology discussions

Click here to view more episodes of our Mind Moments podcast.