Screening for Alzheimer Disease: Facilitating an Early Diagnosis for Prompt Intervention


In this episode of MEDcast, expert geriatric psychiatrists explore the urgent need for effective diagnostic methods that can detect Alzheimer’s disease at an early stage. We will discuss blood-based biomarkers and other advancements that can help screen Alzheimer’s disease non-invasively and early in the disease course.

0:00 Introduction

1:25 An overview of the current standard of care in of Alzheimer’s disease

4:55 Pathophysiology of Alzheimer’s disease

6:58 Aducanumab and lecanemab for Alzheimer’s disease

9:45 Mechanism of action of anti-amyloid agents

11:19 Leaky cell theory in Alzheimer's disease

12:35 Efficacy and safety of aducanumab and lecanemab

13:26 Safety of emerging agents in Alzheimer’s disease

16:37 Practical implementation of lecanemab

19:23 Challenges in CMS coverage for treatments of Alzheimer’s

24:05 Efficacy and safety of Donanemab

25:35 Overcoming clinical inertia around emerging agents in Alzheimer’s disease

29:30 A look into the future of management of Alzheimer’s disease

31:30 Summary

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Anton P. Porsteinsson, MD
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