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|Podcasts|July 20, 2023

Screening for Alzheimer’s Disease: Facilitating an Early Diagnosis for Prompt Intervention

Author(s)Marc Agronin, MD, Stephen Scheinthal, DO, DFACN, DFAPA, CS, Elaine R. Peskind, MD

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In this episode of MEDcast, expert geriatric psychiatrists explore the urgent need for effective diagnostic methods that can detect Alzheimer’s disease at an early stage. We will discuss blood-based biomarkers and other advancements that can help screen Alzheimer’s disease non-invasively and early in the disease course.

To watch the video series component of this episode, click here.

0:00 Introduction

1:25 An overview of the current standard of care in of Alzheimer’s disease

4:55 Pathophysiology of Alzheimer’s disease

6:58 Aducanumab and lecanemab for Alzheimer’s disease

9:45 Mechanism of action of anti-amyloid agents

11:19 Leaky cell theory in Alzheimer's disease

12:35 Efficacy and safety of aducanumab and lecanemab

13:26 Safety of emerging agents in Alzheimer’s disease

16:37 Practical implementation of lecanemab

19:23 Challenges in CMS coverage for treatments of Alzheimer’s

24:05 Efficacy and safety of Donanemab

25:35 Overcoming clinical inertia around emerging agents in Alzheimer’s disease

29:30 A look into the future of management of Alzheimer’s disease

31:30 Summary

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