Switching Patients With Multiple Sclerosis to S1P Receptor Modulator

EP: 1.S1P Receptor Modulators and the Treatment Landscape of Relapsing-Remitting Multiple Sclerosis

EP: 2.Tissue Selectivity of S1P Receptor Modulator

EP: 3.Safety Profile of S1P Receptor Modulators for Multiple Sclerosis

EP: 4.Monitoring Patients With Relapsing-Remitting Multiple Sclerosis on S1P Receptor Modulator

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EP: 5.Switching Patients With Multiple Sclerosis to S1P Receptor Modulator

EP: 6.The Safety Data of Ozanimod in Multiple Sclerosis

EP: 7.The Safety of Other S1P Receptor Modulators in Multiple Sclerosis

EP: 8.Clinical Pearls for Treating Relapsing-Remitting Multiple Sclerosis With S1P Receptor Modulators

EP: 9.S1P Receptor Modulators in Multiple Sclerosis

EP: 10.Selecting S1P Receptor Modulators in Multiple Sclerosis

EP: 11.Long-term Data With Ozanimod in Relapsing-Remitting Multiple Sclerosis

EP: 12.Long-Term Data With Other S1P Receptor Modulators in Multiple Sclerosis

EP: 13.Long-term Immunological Impact of Drug-Modifying Therapies in Multiple Sclerosis

EP: 14.Expert Advice on Multiple Sclerosis Treatment Cessation and Disease Rebound

EP: 15.Emerging Disease-Modifying Therapy Data in Multiple Sclerosis

EP: 16.Final Thoughts on S1P Receptor Modulators in Multiple Sclerosis

Transcript

Krzysztof Selmaj, MD, PhD: Obviously now, assessment of efficacy is important. As with other drugs for MS [multiple sclerosis] that are in the market now, the primary efficacy is measured by [whether the drugs] stop MS development or slow disease development, and this is assessed by clinical measures. We need to evaluate the patients clinically and conduct a regular neurologic exam. Of course, in addition, we should take MRIs, I mentioned that a monitoring MRI should be taken once every year. But if there’s some risk for PML [progressive multifocal leukoencephalopathy], it should be taken immediately. This is from the perspective of effectiveness. From the perspective of safety, as I said, the first adverse effects may occur after 3 to 6 months of treatment. At that time, you also should pay attention to monitoring measures, liver enzymes, OCT [optical coherence tomography], also blood pressure measurements. It’s not very demanding, but this is necessary to monitor for safety.

On the whole, I can say that the tolerance of these drugs is very good. There are long observational studies with the selective S1P [sphingosine-1-phosphate] receptor modulators, in particular with ozanimod, that show a mild safety pattern. And we can follow these monitoring measures to potentially pick up some adverse events. Treatment with these drugs is not particularly difficult, and it’s one of the advantages in relation to some other drugs we are using for multiple sclerosis today.

Transcript edited for clarity.