Tackling Inflammation With Innovative Alzheimer Disease Treatments: Stanley H. Appel, MD
The director of the Ann Kimball and John W. Johnson Center for Cellular Therapeutics at Houston Methodist Hospital talked about the phase 2 study assessing low-dose COYA 301 in mild-to-moderate Alzheimer disease and the focus on inflammation in this patient population. [WATCH TIME: 5 minutes]
WATCH TIME: 5 minutes
“Our innovative therapy, utilizing low-dose COYA 301, holds the promise of not only slowing the rate of progression but potentially offering better outcomes for patients with neurodegenerative diseases."
COYA 301 (Coya Therapeutics), an investigational interleukin-2 (IL-2) treatment, is a combination immunotherapy designed to lower activated T effector cells and activated macrophages/microglia, while increasing peripheral T cell regulatory (Treg) function and numbers. Previous findings from a
In a recent announcement, the randomized, double-blind, placebo-controlled phase 2 study (NCT06096090) of low-dose COYA 301 in patients with mild-to-moderate AD completed enrollment.2 In this study, investigators will assess the safety and tolerability, biological activity, blood and cerebrospinal fluid biomarkers, neuroimaging, and changes in cognitive function of LD IL-2 compared with the placebo at prespecified timepoints in a 21-week treatment period and at 9 weeks after the last dose administered. According to a recent release, the company noted that the topline results of the study are anticipated to be reported in summer 2024.2
Recently, coprincipal investigator
REFERENCES
1. Coya Therapeutics’ COYA 301 increased Treg function and halted cognitive decline in an open-label study in patients with Alzheimer’s disease. News release. Coya Therapeutics. May 16, 2023. Accessed December 6, 2023. https://ir.coyatherapeutics.com/news/news-details/2023/Coya-Therapeutics-COYA-301-Increased-Treg-Function-and-Halted-Cognitive-Decline-in-an-Open-Label-Study-in-Patients-with-Alzheimers-Disease/default.aspx
2. Coya Therapeutics (Coya) Announces Completion of Enrollment in a Well-Controlled Phase 2 Study of Low Dose Interleukin-2 (LD IL-2) in Patients with Alzheimer’s Disease (AD). News Release. Coya Therapeutics. Published October 9, 2023. Accessed December 6, 2023. https://ir.coyatherapeutics.com/news/news-details/2023/Coya-Therapeutics-Coya-Announces-Completion-of-Enrollment-in-a-Well-Controlled-Phase-2-Study-of-Low-Dose-Interleukin-2-LD-IL-2-in-Patients-with-Alzheimers-Disease-AD/default.aspx
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