
Understanding Donanemab’s Clinical Relevance for Patients With Alzheimer Disease: Alireza Atri, MD, PhD
The director of the Banner Sun Health Research Institute provided commentary on his presentation at CTAD 2023 examining the value of donanemab and its effect on specific Alzheimer-related assessments. [WATCH TIME: 10 minutes]
WATCH TIME: 10 minutes
"We’re in a great era, a hopeful era, but we’re at the end of the beginning. We’ve got a lot of work to do to translate these things, understand them. We understand they’re foundational, they’re not curative by any means. Part of this is that the measures we use in clinical trials are not medically understandable to even more trialists because we don’t use them in clinical practice."
Over the years, there has been an increased interest in the outcomes of randomized controlled trials assessing agents for early-stage mild cognitive impairment (MCI) or mild dementia due to Alzheimer disease (AD). Following the controversial approval of aducanumab (Aduhelm; Biogen) in 2021, many in the field pleaded for more transparency among industry leaders with the presentation of data for potential therapies and the effects they demonstrate.
Earlier this year, Eli Lilly
At the
REFERENCE
1. Sims JR, Zimmer JA, Evans CD, et al. Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial. JAMA. Published online July 17, 2023. doi:10.1001/jama.2023.13239
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