Isabella Ciccone, Assistant Editor, NeurologyLive®, has been with the team since September 2022. Follow her on Twitter @iciccone7 or email her at email@example.com
Rituximab Treatment Associated with Reduced Relapse Rate in AQP4-IgG Positive NMOSD and MOGAD
A study using patient data from John Hopkins showed that rituximab treatment was associated with reduced annualized relapse rates in AQP4-IgG seropositive NMOSD and MOGAD.
Day-of-injury Plasma GFAP and UCH-L1 Predict Functional Recovery After Traumatic Brain Injury
The TRACK-TBI cohort study revealed that patients with traumatic brain injury and a GCS score of 3 to 12 had a significant increase in the accuracy of prognostic accuracy of IMPACT models.
Combination of MSBASE Prediction Model and Multiple Sclerosis Severity Score Improves Accuracy of Individualized Prediction in MS
Data from a MSbase registry on patients with multiple sclerosis show in its findings that the incorporation of the Multiple Sclerosis Severity Score improved the prediction accuracy of relapses in MS.
Combination of Biomarkers Associated with Stronger Predictions of Progression in Parkinson Disease
Findings from a study on Parkinson disease revealed that combining blood biomarkers in addition with clinical measures with prognostics modelling are associated with a more vital prediction in disease progression.
High Flow Oxygen As Acute Therapy is Most Optimal for Headache Relief
Recent findings from a network meta-analysis suggest that high flow oxygen is more efficacious when compared with low flow oxygen for headache relief.
Cluster Headache Prevention Clinical Trials Need to Focus on Efficacy, Natural History of Disease
A narrative review revealed that cluster headache trials have been limited thus far, and that future trials should include novel outcome measures and adjusted end point timing.
Crenezumab Does Not Reduce Clinical Decline in Adults With Early Alzheimer Disease
In 2 phase 3 randomized placebo-controlled trials, findings showed that although crenezumab was well tolerated, it did not reduce clinical decline in participants with early Alzheimer disease.
Majority of Canadian Physicians Treat Primary Headache Disorders With Nonsteroidal Anti-inflammatory Drugs, Dopamine Receptor Antagonists
A national survey showed in its findings that NSAIDs alone and dopamine receptor antagonists are used commonly for treating primary headache disorders in Canadian emergency departments.
Ketogenic Diet Results in Reduced Weight, Fatigue, and Depression in Relapsing Multiple Sclerosis
In a recent phase 2 study, 6-months of ketogenic diet for people with relapsing multiple sclerosis resulted in a significant reduction in weight, fatigue, and depression, and improved quality of life.
Ublituximab Reduces Relapses Compared With Teriflunomide in Multiple Sclerosis
In a phase 3 trial, ULTIMATE I and II, ublituximab resulted in lower annualized relapse rates and fewer brain lesions on MRI than teriflunomide among participants with relapsing multiple sclerosis.
Virtual Yoga Program Beneficial for Individuals With Functional Neurological Disorder
Danielle Kipnis, MA, of Columbia University, discussed the practice of yoga for people with functional neurological disorders from her research and recommendations for future studies in the field.
Current Alzheimer Research and Recommendations for Future Clinical Trials
With diagnosis rates of Alzheimer disease increasing, Tabby Khan, MD, MPH, spoke to the need to focus on cognitive decline in younger patient populations.
Nonpharmacologic Interventions Improve Sleep Time in Hospitalized Patients
Findings from a nonrandomized controlled trial in the Netherlands suggest that sleep time of hospitalized patients may be significantly improved with nonpharmacologic interventions such as the postponement of morning vital sign checks and medication administration rounds from the night to the day shift.
CNM-Au8 Slows Disease Progression in ALS in RESCUE-ALS Phase 2 Trial
RESCUE-ALS trial, a phase 2 randomized controlled study, showed that ALS disease progression was significantly reduced with CNM-Au8 Treatment.
Electroacupuncture for Insomnia Significantly Improves Quality of Sleep in Patients With Depression
In a randomized clinical trial, the application of electroacupuncture treatment for insomnia in patients with depression significantly improved the quality of sleep in comparison with sham acupuncture or the control group.
Sleep Breathing Disorders Appear Common for Patients with Duchenne Muscular Dystrophy
A questionnaire-based study from Saudi Arabia on sleep quality revealed that sleep-related disorders, such as obstructive sleep apnea, are relatively common in patients with Duchenne muscular dystrophy.
Diagnosis of Myotonic Dystrophy Demonstrates an Association With Depression
Findings from a cross-sectional survey revealed a significant association between depression and a diagnosis of myotonic dystrophy, and that symptoms impacting quality of life are more common in neuromuscular disorders.
Tollgate-Related Prognostic Factors Have Stronger Effect on ALS Progression Timing Through Disease Tollgates
A study on ALS progression suggested that tollgate-related prognostic factors have a stronger effect on the time trajectories of passing ALS tollgates in comparison with standard prognostic factors.
Acupuncture Proves Effective as Method to Improve Sleep Quality for Post-Stroke Insomnia
In a randomized controlled trial, results demonstrated that acupuncture is to be efficacious in improving insomnia, quality of life, and affective symptoms for patients with ischemic stroke.
Virtual Reality Training May Improve Quality of Care in Lower Limb Spasticity With OnabotulinumtoxinA
Results from pilot program using a VR-based platform suggest medical trainees may benefit from further VR training to gain a complete baseline knowledge of treating lower limb spasticity with onabotulinumtoxinA.
Tele-Yoga Breathing for Respiratory Function Proves Feasibility in Amyotrophic Lateral Sclerosis
A nonrandomized pilot study demonstrated high adherence rates and acceptability ratings with tele-yoga breathing in patients with ALS, proving that it is a safe and feasible practice.
Vaccinated Individuals With Myasthenia Gravis With COVID-19 Infection are More at Health Risk
Adults with myasthenia gravis who contracted COVID-19 were at twice the risk of hospitalization, ICU admission, and death based on data from a recent population-based study.
Patients Receiving Efgartigimod Respond to COVID-19 Vaccination With IgG Antibodies
In an investigation on the effect of treatment with efgartigimod on humoral immune responses to COVID-19 vaccination, the immunization resulted in antigen-specific IgG responses in most patients.
Repetitive Nerve Stimulation Exhibits Positive Association with Inpatient Diagnosis of Myasthenia Gravis
Findings from retrospective study show that repetitive nerve stimulation is a highly sensitive and specific test for the diagnosis of myasthenia gravis in an inpatient setting, with its results being more rapidly available in comparison with antibody testing.
Eplontersin Treatment Results in Reduction in Serum Transthyretin in Amyloidosis
Eplontersen treatment resulted in a significant reduction in transthyretin, neuropathy impairment, and improvement in quality of life in the phase 3 NEURO-TTRansform study of patients with hereditary transthyretin amyloidosis.
Pooled Clinical Trial Data Suggests Antidrug Antibody Testing for Alglucosidase Alfa-Exposed Patients With Pompe Disease
Investigators concluded that those receiving avalglucosidase alfa should be tested for antidrug antibodies by physicians who treat Pompe disease and monitor antidrug antibody, according to a recent Sanofi investigation.
ADAPT/ADAPT+ Study Show Improvements in Myasthenia Gravis Efficacy Scales With Efgartigimod
ADAPT+ study data on antiacetylcholine receptor antibody-negative patients with generalized myasthenia gravis found improvements in cycle baseline and efficacy with Efgartigimod.
CNM-Au8 Displays Evidence of Survival Benefit in Amyotrophic Lateral Sclerosis
Results from phase 2 RESCUE-ALS trial show that treatment with CNM-Au8 in ALS demonstrated improvement in survival compared to the estimated median survival rate.
Cipaglucosidase Alfa/Miglustat Shows Beneficial Treatment Effects for Patients With Late-onset Pompe Disease
Most ambulatory patients had improved pulmonary functions and biomarker outcomes with cipaglucosidase alfa/miglustat that were sustained through a less than 36-month follow-up period.
Endovascular Therapy Shows Better Functional Outcomes for Acute Stroke
A trial conducted in Japan showed better functional outcomes for patients with large cerebral infarctions treated with endovascular therapy than those treated with medical care alone, but had more intracranial hemorrhages.
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